"In vitro" effects of different arsenic compounds on PBMC (preliminary study)
Aim of this investigation was to compare the effects of 10(-4) M and 10(-7) M As compounds on spontaneous and PHA stimulated PBMC proliferation and IFN-gamma and TNF-alpha release. The inhibitory effect of the 10(-4) M As salts was in the following order: momo-methyl-arsinous acic (MMAs(III)) > s...
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| Veröffentlicht in: | Giornale italiano di medicina del lavoro ed ergonomia 2004-07, Vol.26 (3), p.183 |
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| container_title | Giornale italiano di medicina del lavoro ed ergonomia |
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| creator | Di Giampaolo, L Di Gioacchino, M Qiao, Niu Travaglini, P D'Intino, A Kouri, M Ponti, J Castellani, M L Reale, M Gabriele, E Boscolo, P |
| description | Aim of this investigation was to compare the effects of 10(-4) M and 10(-7) M As compounds on spontaneous and PHA stimulated PBMC proliferation and IFN-gamma and TNF-alpha release. The inhibitory effect of the 10(-4) M As salts was in the following order: momo-methyl-arsinous acic (MMAs(III)) > sodium arsenite (As(III)) > tetraphenyl arsonium chloride (As(V)) > sodium arsenate (As(V)) > potassium- and sodium-esa-fluorum arsenate (As(V)) > dimethyl arsinic acid (DMAs(V)), while monomethyl-arsonic-acid (MMAs(V)) and arsenobetaine did not exert immune effects. 10(-7) M MMAs(III) stimulated the spontaneous PBMC proliferation, while As(III) and DMAs(V) enhanced the PHA stimulated PBMC proliferation. This study shows that the immune effects of As salts depends on speciation; moreover, the immunotoxicity of inorganic arsenic in part depends on the intracellular bio-synthesis of MMAs(III) from MMAs(V). |
| format | Article |
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The inhibitory effect of the 10(-4) M As salts was in the following order: momo-methyl-arsinous acic (MMAs(III)) > sodium arsenite (As(III)) > tetraphenyl arsonium chloride (As(V)) > sodium arsenate (As(V)) > potassium- and sodium-esa-fluorum arsenate (As(V)) > dimethyl arsinic acid (DMAs(V)), while monomethyl-arsonic-acid (MMAs(V)) and arsenobetaine did not exert immune effects. 10(-7) M MMAs(III) stimulated the spontaneous PBMC proliferation, while As(III) and DMAs(V) enhanced the PHA stimulated PBMC proliferation. 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The inhibitory effect of the 10(-4) M As salts was in the following order: momo-methyl-arsinous acic (MMAs(III)) > sodium arsenite (As(III)) > tetraphenyl arsonium chloride (As(V)) > sodium arsenate (As(V)) > potassium- and sodium-esa-fluorum arsenate (As(V)) > dimethyl arsinic acid (DMAs(V)), while monomethyl-arsonic-acid (MMAs(V)) and arsenobetaine did not exert immune effects. 10(-7) M MMAs(III) stimulated the spontaneous PBMC proliferation, while As(III) and DMAs(V) enhanced the PHA stimulated PBMC proliferation. This study shows that the immune effects of As salts depends on speciation; moreover, the immunotoxicity of inorganic arsenic in part depends on the intracellular bio-synthesis of MMAs(III) from MMAs(V).</description><subject>Animals</subject><subject>Arsenates - adverse effects</subject><subject>Arsenic - adverse effects</subject><subject>Arsenicals - adverse effects</subject><subject>Arsenites - adverse effects</subject><subject>Cell Proliferation</subject><subject>Cells, Cultured</subject><subject>Data Interpretation, Statistical</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>In Vitro Techniques</subject><subject>Interferon-gamma - analysis</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Leukocytes, Mononuclear - cytology</subject><subject>Leukocytes, Mononuclear - drug effects</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Male</subject><subject>Phytohemagglutinins - pharmacology</subject><subject>Rats</subject><subject>Sodium Compounds - adverse effects</subject><subject>Stimulation, Chemical</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><issn>1592-7830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j0tLAzEcxHNQbKn9ChJ60sNCHpuke9TFR6FFD3ouefwDkW42JLtCv70B7VxmYGD4zRVaUtGxRm05WaB1Kd-kShImqbpBCyqEoF2rluiw2UX8E6Y8bjB4D3YqePTYhZozxAnrXCAGi-04pHGOrtYRfzwdenyfMpzCEKLOZ1ym2Z0fbtG116cC639foa-X58_-rdm_v-76x32TKGNTI3nFMNxKsJaziqWZlVJq3nrCDFEA1nBvHO8II6Bo17Vsa4kjXHsqjOIrdPe3m2YzgDumHIZKcbz84r9wWkhN</recordid><startdate>200407</startdate><enddate>200407</enddate><creator>Di Giampaolo, L</creator><creator>Di Gioacchino, M</creator><creator>Qiao, Niu</creator><creator>Travaglini, P</creator><creator>D'Intino, A</creator><creator>Kouri, M</creator><creator>Ponti, J</creator><creator>Castellani, M L</creator><creator>Reale, M</creator><creator>Gabriele, E</creator><creator>Boscolo, P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200407</creationdate><title>"In vitro" effects of different arsenic compounds on PBMC (preliminary study)</title><author>Di Giampaolo, L ; 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The inhibitory effect of the 10(-4) M As salts was in the following order: momo-methyl-arsinous acic (MMAs(III)) > sodium arsenite (As(III)) > tetraphenyl arsonium chloride (As(V)) > sodium arsenate (As(V)) > potassium- and sodium-esa-fluorum arsenate (As(V)) > dimethyl arsinic acid (DMAs(V)), while monomethyl-arsonic-acid (MMAs(V)) and arsenobetaine did not exert immune effects. 10(-7) M MMAs(III) stimulated the spontaneous PBMC proliferation, while As(III) and DMAs(V) enhanced the PHA stimulated PBMC proliferation. This study shows that the immune effects of As salts depends on speciation; moreover, the immunotoxicity of inorganic arsenic in part depends on the intracellular bio-synthesis of MMAs(III) from MMAs(V).</abstract><cop>Italy</cop><pmid>15551947</pmid></addata></record> |
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| ispartof | Giornale italiano di medicina del lavoro ed ergonomia, 2004-07, Vol.26 (3), p.183 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Arsenates - adverse effects Arsenic - adverse effects Arsenicals - adverse effects Arsenites - adverse effects Cell Proliferation Cells, Cultured Data Interpretation, Statistical Humans Immunoenzyme Techniques In Vitro Techniques Interferon-gamma - analysis Interferon-gamma - biosynthesis Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Male Phytohemagglutinins - pharmacology Rats Sodium Compounds - adverse effects Stimulation, Chemical Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - biosynthesis |
| title | "In vitro" effects of different arsenic compounds on PBMC (preliminary study) |
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