Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease

The amyloid beta-protein (Abeta) ending at 42 plays a pivotal role in Alzheimer's disease (AD). We have reported previously that intracellular Abeta42 is associated with neuronal apoptosis in vitro and in vivo. Here, we show that intracellular Abeta42 directly activated the p53 promoter, result...

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Veröffentlicht in:	The FASEB journal 2005-02, Vol.19 (2), p.255
Hauptverfasser:	Ohyagi, Yasumasa, Asahara, Hideaki, Chui, De-Hua, Tsuruta, Yuko, Sakae, Nobutaka, Miyoshi, Katsue, Yamada, Takeshi, Kikuchi, Hitoshi, Taniwaki, Takayuki, Murai, Hiroyuki, Ikezoe, Koji, Furuya, Hirokazu, Kawarabayashi, Takeshi, Shoji, Mikio, Checler, Frederic, Iwaki, Toru, Makifuchi, Takao, Takeda, Kazuya, Kira, Jun-ichi, Tabira, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - physiology Amyloid beta-Protein Precursor - genetics Animals Apoptosis - genetics Apoptosis - physiology Brain - cytology Brain - metabolism Brain - pathology Brain Chemistry - genetics Cells, Cultured Cytosol - chemistry DNA - metabolism Female Fetus Genes, p53 - genetics Guinea Pigs Heat-Shock Response - genetics Humans Hydrogen Peroxide - pharmacology Intracellular Space - chemistry Intracellular Space - metabolism Intracellular Space - pathology Leucine - genetics Male Membrane Proteins - genetics Mice Mice, Mutant Strains Mice, Transgenic Mutation, Missense - genetics Nerve Degeneration - metabolism Nerve Degeneration - pathology Neuroblastoma - pathology Neurons - chemistry Neurons - metabolism Peptide Fragments - metabolism Peptide Fragments - physiology Presenilin-1 Promoter Regions, Genetic - genetics Promoter Regions, Genetic - physiology Protein Binding Response Elements - physiology RNA, Messenger - genetics RNA, Messenger - metabolism Tumor Cells, Cultured Tumor Suppressor Protein p53 - biosynthesis Valine - genetics
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