Polymer Design and Incorporation Methods for Polymeric Micelle Carrier System Containing Water-insoluble Anti-cancer Agent Camptothecin

A water-insoluble anti-cancer agent, camptothecin (CPT) was incorporated to a polymeric micelle carrier system forming from poly(ethylene glycol)-poly(aspartate) block copolymers. Incorporation efficiency and stability were analyzed in correlation with chemical structures of the inner core-forming h...

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Veröffentlicht in:	Journal of drug targeting 2004-07, Vol.12 (6), p.373-384
Hauptverfasser:	Yokoyama, Masayuki, Opanasopit, Praneet, Okano, Teruo, Kawano, Kumi, Maitani, Yoshie
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - chemistry Biological and medical sciences Block copolymer Camptothecin Camptothecin - administration & dosage Camptothecin - chemistry Dialysis Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Compounding Drug Stability Emulsions Esterification Esters - chemical synthesis General pharmacology Hydrolysis Medical sciences Micelles Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly (aspartic acid) Poly (ethylene glycol) Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Polymeric micelle Proteins - chemical synthesis Proteins - chemistry Solubility Targeting Water - chemistry
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