Different cation sensitivities and binding site domains of Na+-Ca2+-K+ and Na+-Ca2+ exchangers

We examined inhibitory effects of external multivalent cations Ni2+, Co2+, Cd2+, La3+, Mg2+, and Mn2+ on reverse‐mode exchange of the K+‐dependent Na+/Ca2+ exchanger NCKX2 and the K+‐independent exchanger NCX1 expressed in CCL‐39 cells by measuring the rate of Ca2+ uptake with radioisotope tracer an...

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Veröffentlicht in:	Journal of cellular physiology 2005-05, Vol.203 (2), p.420-428
Hauptverfasser:	Uehara, Akira, Iwamoto, Takahiro, Kita, Satomi, Shioya, Takao, Yasukochi, Midori, Nakamura, Yuki, Imanaga, Issei
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs - drug effects Amino Acid Motifs - physiology Amino Acid Sequence Amino Acids - genetics Animals Binding Sites - drug effects Binding Sites - physiology Binding, Competitive - physiology Cadmium - metabolism Cadmium - pharmacology Cations - metabolism Cations - pharmacology Cell Line Cell Membrane - chemistry Cell Membrane - drug effects Cell Membrane - metabolism Cobalt - metabolism Cobalt - pharmacology Cricetinae Extracellular Space - chemistry Lanthanum - metabolism Lanthanum - pharmacology Magnesium - metabolism Magnesium - pharmacology Manganese - metabolism Manganese - pharmacology Models, Molecular Molecular Sequence Data Mutation - physiology Nickel - metabolism Nickel - pharmacology Potassium - metabolism Potassium - pharmacology Protein Structure, Tertiary - drug effects Protein Structure, Tertiary - physiology Rats Sequence Homology, Amino Acid Sodium-Calcium Exchanger - chemistry Sodium-Calcium Exchanger - drug effects Sodium-Calcium Exchanger - metabolism
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