Fetal alcohol exposure impairs alveolar macrophage function via decreased glutathione availability

Immature function of the alveolar macrophage increases the risk of pulmonary infections in premature newborns. In utero alcohol increases fetal systemic oxidative stress. Because the premature lung is deficient in glutathione (GSH), we hypothesized that chronic in utero alcohol (ethanol) exposure ex...

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Veröffentlicht in:	Pediatric research 2005, Vol.57 (1), p.76-81
Hauptverfasser:	GAUTHIER, Theresa W, PING, Xiao-Du, HARRIS, Frank L, WONG, Michael, ELBAHESH, Husni, BROWN, Lou Ann. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Drinking - adverse effects Animals Apoptosis Biological and medical sciences Cell Survival Central Nervous System Depressants - adverse effects Disease Models, Animal Epithelium - pathology Ethanol - adverse effects Ethanol - pharmacology Female General aspects Glutathione - metabolism Guinea Pigs In Situ Nick-End Labeling Lipid Peroxidation Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Maternal Exposure Medical sciences Oxidative Stress Phagocytosis S-Adenosylmethionine - pharmacology Time Factors
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