Intracochlear Perfusion of Pneumolysin, a Pneumococcal Protein, Rapidly Abolishes Auditory Potentials in the Guinea Pig Cochlea

Objective -Bacterial meningitis and chronic suppurative otitis media caused by Streptococcus pneumoniae are associated with considerable otological morbidity. Specifically, sensorineural hearing loss is a permanent sequela in a third of those who contract pneumococcal meningitis. Pneumolysin, a pneu...

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Veröffentlicht in:	Acta oto-laryngologica 2004-11, Vol.124 (9), p.1000-1007
Hauptverfasser:	Skinner, Liam J., Beurg, Maryline, Mitchell, Timothy J., Darrouzet, Vincent, Aran, Jean-marie, Dulon, Didier
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation - methods Animals Audiometry, Evoked Response - methods auditory potentials Bacterial Proteins - toxicity Biological and medical sciences cochlea Cochlea - drug effects Female Guinea Pigs hair cells Hearing Loss, Sensorineural - etiology Male Medical sciences Otitis Media - complications Otorhinolaryngology. Stomatology perfusion pneumolysin Reflex, Acoustic - drug effects Streptococcus pneumoniae Streptolysins - toxicity
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