Protective effect of vilva juice on glycoconjugate levels in experimentally induced constipation in rats

Efficacy of vilva, a polyherbal formulation was evaluated in morphine induced constipated rats. Vilva juice, at a dose of 1.5 ml/100 g body wt was given orally for a period of 7 days. Morphine sulfate was injected to induce constipation on 8th day, 45 min before the experiments. Protein bound glycoc...

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Veröffentlicht in:	Indian journal of experimental biology 2004-10, Vol.42 (10), p.1024
Hauptverfasser:	Padmini, R, Sabitha, K E, Devi, C S Shyamala
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colon - drug effects Colon - metabolism Colon - pathology Constipation - chemically induced Constipation - drug therapy Constipation - metabolism Female Glycoconjugates - metabolism Morphine - toxicity Phytotherapy Plant Preparations - therapeutic use Rats Rats, Wistar
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Zusammenfassung:	Efficacy of vilva, a polyherbal formulation was evaluated in morphine induced constipated rats. Vilva juice, at a dose of 1.5 ml/100 g body wt was given orally for a period of 7 days. Morphine sulfate was injected to induce constipation on 8th day, 45 min before the experiments. Protein bound glycoconjungates were estimated in intestinal tissue. Altered levels of glycoconjugates were maintained at near normalcy when pretreated with vilva juice in morphine induced rats. Histological changes were observed in the colon tissue. The damage to crypts of Liberkunn in constipated rats were found to be reduced in vilva pretreated rats. Vilva, thus, offered significant protection against morphine induced constipation by way of augmenting mucus secretion.
ISSN:	0019-5189