Adrenal Steroid Hormones and Metaphyseal Bone in Children
Background/Objectives: The responses of metaphyseal bone tissue to physiological variations of endogenous adrenal steroid hormones during childhood are unclear. Therefore, we studied potential hormonal influences in children before the appearance of pubic hair (onset of pubarche). Methods: Excretion...
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| Veröffentlicht in: | Hormone research 2004-01, Vol.62 (5), p.221-226 |
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| creator | Remer, Thomas Boye, Kai R. Hartmann, Michaela F. Neu, Christina Schoenau, Eckhard Manz, Friedrich Wudy, Stefan A. |
| description | Background/Objectives: The responses of metaphyseal bone tissue to physiological variations of endogenous adrenal steroid hormones during childhood are unclear. Therefore, we studied potential hormonal influences in children before the appearance of pubic hair (onset of pubarche). Methods: Excretions of major glucocorticoid metabolites (C21), cortisol, sum of adrenarchal dehydroepiandrosterone and its immediate 16-hydroxylated metabolites (DHEA&M), and 5-androstene-3β,17β-diol (hermaphrodiol) were analyzed in a cross-sectional study in 24-hour urine samples of 109 healthy boys and girls, aged 6–13 years, using steroid profiling by gas chromatography-mass spectrometry. Total and trabecular volumetric bone mineral densities, bone mineral content (BMC) and bone strength strain index were determined with peripheral quantitative computed tomography at the distal forearm. Results: In multiple regression analyses significant associations with the metaphyseal radius were seen for grip force, age, or BMI depending on gender and bone variable analyzed. DHEA&M did not contribute to the explanation of the variance of any bone variable. However, hermaphrodiol positively explained a significant part of variation of bone mineral densities, and BMC (p < 0.01) in girls. Significantly negative associations with all bone variables were seen in boys for cortisol. Conclusions: The steroid hormones, cortisol and hermaphrodiol, in their physiological ranges, but not the adrenarche marker DHEA&M, appear to associate with metaphyseal bone in a sex-dependent manner during childhood. |
| doi_str_mv | 10.1159/000081349 |
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Therefore, we studied potential hormonal influences in children before the appearance of pubic hair (onset of pubarche). Methods: Excretions of major glucocorticoid metabolites (C21), cortisol, sum of adrenarchal dehydroepiandrosterone and its immediate 16-hydroxylated metabolites (DHEA&M), and 5-androstene-3β,17β-diol (hermaphrodiol) were analyzed in a cross-sectional study in 24-hour urine samples of 109 healthy boys and girls, aged 6–13 years, using steroid profiling by gas chromatography-mass spectrometry. Total and trabecular volumetric bone mineral densities, bone mineral content (BMC) and bone strength strain index were determined with peripheral quantitative computed tomography at the distal forearm. Results: In multiple regression analyses significant associations with the metaphyseal radius were seen for grip force, age, or BMI depending on gender and bone variable analyzed. DHEA&M did not contribute to the explanation of the variance of any bone variable. However, hermaphrodiol positively explained a significant part of variation of bone mineral densities, and BMC (p < 0.01) in girls. Significantly negative associations with all bone variables were seen in boys for cortisol. Conclusions: The steroid hormones, cortisol and hermaphrodiol, in their physiological ranges, but not the adrenarche marker DHEA&M, appear to associate with metaphyseal bone in a sex-dependent manner during childhood.</description><identifier>ISSN: 1663-2818</identifier><identifier>ISSN: 0301-0163</identifier><identifier>EISSN: 1663-2826</identifier><identifier>DOI: 10.1159/000081349</identifier><identifier>PMID: 15475655</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adolescent ; Adrenal Cortex Hormones - urine ; Bone and Bones - anatomy & histology ; Bone and Bones - metabolism ; Bone Density ; Child ; Cross-Sectional Studies ; Dehydroepiandrosterone - urine ; Female ; Humans ; Hydrocortisone - urine ; Male ; Original Paper ; Steroids - urine</subject><ispartof>Hormone research, 2004-01, Vol.62 (5), p.221-226</ispartof><rights>2004 S. Karger AG, Basel</rights><rights>Copyright (c) 2004 S. Karger AG, Basel.</rights><rights>Copyright (c) 2004 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-eb67de8cf68e6df668b31e65ee14df5a2cdd00863e850ae7350a4cffe2feaf153</citedby><cites>FETCH-LOGICAL-c360t-eb67de8cf68e6df668b31e65ee14df5a2cdd00863e850ae7350a4cffe2feaf153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2430,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15475655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Remer, Thomas</creatorcontrib><creatorcontrib>Boye, Kai R.</creatorcontrib><creatorcontrib>Hartmann, Michaela F.</creatorcontrib><creatorcontrib>Neu, Christina</creatorcontrib><creatorcontrib>Schoenau, Eckhard</creatorcontrib><creatorcontrib>Manz, Friedrich</creatorcontrib><creatorcontrib>Wudy, Stefan A.</creatorcontrib><title>Adrenal Steroid Hormones and Metaphyseal Bone in Children</title><title>Hormone research</title><addtitle>Horm Res Paediatr</addtitle><description>Background/Objectives: The responses of metaphyseal bone tissue to physiological variations of endogenous adrenal steroid hormones during childhood are unclear. Therefore, we studied potential hormonal influences in children before the appearance of pubic hair (onset of pubarche). Methods: Excretions of major glucocorticoid metabolites (C21), cortisol, sum of adrenarchal dehydroepiandrosterone and its immediate 16-hydroxylated metabolites (DHEA&M), and 5-androstene-3β,17β-diol (hermaphrodiol) were analyzed in a cross-sectional study in 24-hour urine samples of 109 healthy boys and girls, aged 6–13 years, using steroid profiling by gas chromatography-mass spectrometry. Total and trabecular volumetric bone mineral densities, bone mineral content (BMC) and bone strength strain index were determined with peripheral quantitative computed tomography at the distal forearm. Results: In multiple regression analyses significant associations with the metaphyseal radius were seen for grip force, age, or BMI depending on gender and bone variable analyzed. DHEA&M did not contribute to the explanation of the variance of any bone variable. However, hermaphrodiol positively explained a significant part of variation of bone mineral densities, and BMC (p < 0.01) in girls. Significantly negative associations with all bone variables were seen in boys for cortisol. Conclusions: The steroid hormones, cortisol and hermaphrodiol, in their physiological ranges, but not the adrenarche marker DHEA&M, appear to associate with metaphyseal bone in a sex-dependent manner during childhood.</description><subject>Adolescent</subject><subject>Adrenal Cortex Hormones - urine</subject><subject>Bone and Bones - anatomy & histology</subject><subject>Bone and Bones - metabolism</subject><subject>Bone Density</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Dehydroepiandrosterone - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - urine</subject><subject>Male</subject><subject>Original Paper</subject><subject>Steroids - urine</subject><issn>1663-2818</issn><issn>0301-0163</issn><issn>1663-2826</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0M9LwzAUB_AgihtzB8-CFATBQzVpmh89zqFOmHhQzyVrXlxn28ykPey_N6VjghdzSEL4vMfLF6Fzgm8JYdkdDksSmmZHaEw4p3EiE358uBM5QlPvNz2jUmREnKIRYalgnLExymbaQaOq6K0FZ0sdLayrbQM-Uo2OXqBV2_XOQwD34TUqm2i-Lqu-5gydGFV5mO7PCfp4fHifL-Ll69PzfLaMC8pxG8OKCw2yMFwC14ZzuaIEOAMgqTZMJYXW4QOcgmRYgaBhTwtjIDGgDGF0gq6HvltnvzvwbV6XvoCqUg3Yzudc4IxSkf4LiQgDJbKHV3_gxnYuhBAMEVgwnDEc1M2gCme9d2DyrStr5XY5wXmffH5IPtjLfcduVYP-lfucA7gYwJdyn-AOYCj_AY2ghLc</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Remer, Thomas</creator><creator>Boye, Kai R.</creator><creator>Hartmann, Michaela F.</creator><creator>Neu, Christina</creator><creator>Schoenau, Eckhard</creator><creator>Manz, Friedrich</creator><creator>Wudy, Stefan A.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>Adrenal Steroid Hormones and Metaphyseal Bone in Children</title><author>Remer, Thomas ; Boye, Kai R. ; Hartmann, Michaela F. ; Neu, Christina ; Schoenau, Eckhard ; Manz, Friedrich ; Wudy, Stefan A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-eb67de8cf68e6df668b31e65ee14df5a2cdd00863e850ae7350a4cffe2feaf153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adrenal Cortex Hormones - urine</topic><topic>Bone and Bones - anatomy & histology</topic><topic>Bone and Bones - metabolism</topic><topic>Bone Density</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Dehydroepiandrosterone - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - urine</topic><topic>Male</topic><topic>Original Paper</topic><topic>Steroids - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Remer, Thomas</creatorcontrib><creatorcontrib>Boye, Kai R.</creatorcontrib><creatorcontrib>Hartmann, Michaela F.</creatorcontrib><creatorcontrib>Neu, Christina</creatorcontrib><creatorcontrib>Schoenau, Eckhard</creatorcontrib><creatorcontrib>Manz, Friedrich</creatorcontrib><creatorcontrib>Wudy, Stefan A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Proquest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Remer, Thomas</au><au>Boye, Kai R.</au><au>Hartmann, Michaela F.</au><au>Neu, Christina</au><au>Schoenau, Eckhard</au><au>Manz, Friedrich</au><au>Wudy, Stefan A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adrenal Steroid Hormones and Metaphyseal Bone in Children</atitle><jtitle>Hormone research</jtitle><addtitle>Horm Res Paediatr</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>62</volume><issue>5</issue><spage>221</spage><epage>226</epage><pages>221-226</pages><issn>1663-2818</issn><issn>0301-0163</issn><eissn>1663-2826</eissn><abstract>Background/Objectives: The responses of metaphyseal bone tissue to physiological variations of endogenous adrenal steroid hormones during childhood are unclear. Therefore, we studied potential hormonal influences in children before the appearance of pubic hair (onset of pubarche). Methods: Excretions of major glucocorticoid metabolites (C21), cortisol, sum of adrenarchal dehydroepiandrosterone and its immediate 16-hydroxylated metabolites (DHEA&M), and 5-androstene-3β,17β-diol (hermaphrodiol) were analyzed in a cross-sectional study in 24-hour urine samples of 109 healthy boys and girls, aged 6–13 years, using steroid profiling by gas chromatography-mass spectrometry. Total and trabecular volumetric bone mineral densities, bone mineral content (BMC) and bone strength strain index were determined with peripheral quantitative computed tomography at the distal forearm. Results: In multiple regression analyses significant associations with the metaphyseal radius were seen for grip force, age, or BMI depending on gender and bone variable analyzed. DHEA&M did not contribute to the explanation of the variance of any bone variable. However, hermaphrodiol positively explained a significant part of variation of bone mineral densities, and BMC (p < 0.01) in girls. Significantly negative associations with all bone variables were seen in boys for cortisol. Conclusions: The steroid hormones, cortisol and hermaphrodiol, in their physiological ranges, but not the adrenarche marker DHEA&M, appear to associate with metaphyseal bone in a sex-dependent manner during childhood.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>15475655</pmid><doi>10.1159/000081349</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adrenal Cortex Hormones - urine Bone and Bones - anatomy & histology Bone and Bones - metabolism Bone Density Child Cross-Sectional Studies Dehydroepiandrosterone - urine Female Humans Hydrocortisone - urine Male Original Paper Steroids - urine |
| title | Adrenal Steroid Hormones and Metaphyseal Bone in Children |
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