Acetylcholine-induced relaxation of rabbit basilar artery in vitro is rapidly reduced by reactive oxygen species in acute hyperglycemia: role of NADPH oxidase

We examined the effects of acute hyperglycemia on the function of rabbit cerebral arteries in vitro. It was hypothesized that increased formation of reactive oxygen species (ROS) could occur, which could explain how hyperglycemia aggravates certain pathologic situations such as cerebral ischemia. Th...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2004-10, Vol.44 (4), p.507
Hauptverfasser:	Sercombe, Richard, Vicaut, Eric, Oudart, Nicole, Sercombe, Christine, Girard, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Acute Disease Animals Basilar Artery - drug effects Basilar Artery - metabolism Basilar Artery - physiology Enzyme Inhibitors - pharmacology Free Radical Scavengers - pharmacology Glucose - pharmacology Hyperglycemia - metabolism Hyperglycemia - physiopathology In Vitro Techniques Male NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - metabolism Osmolar Concentration Rabbits Reactive Oxygen Species - metabolism Vasodilation - drug effects Vasodilator Agents - pharmacology
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