NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium

Little is known about the defensive mechanisms induced in epithelial cells by pathogenic versus probiotic bacteria. The aim of our study was to compare probiotic bacterial strains such as Escherichia coli Nissle 1917 with nonprobiotic, pathogenic and nonpathogenic bacteria with respect to innate def...

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Veröffentlicht in:	Infection and immunity 2004-10, Vol.72 (10), p.5750
Hauptverfasser:	Wehkamp, Jan, Harder, Jürgen, Wehkamp, Kai, Wehkamp-von Meissner, Birte, Schlee, Miriam, Enders, Corinne, Sonnenborn, Ulrich, Nuding, Sabine, Bengmark, Stig, Fellermann, Klaus, Schröder, Jens Michael, Stange, Eduard F
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Defensins - genetics Binding Sites Caco-2 Cells Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - microbiology Escherichia coli - classification Escherichia coli - physiology Gene Expression Regulation - drug effects Humans Intestines - cytology Intestines - microbiology JNK Mitogen-Activated Protein Kinases Lipopolysaccharides - pharmacology Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism p38 Mitogen-Activated Protein Kinases Promoter Regions, Genetic - genetics Response Elements - genetics Signal Transduction - drug effects Transcription Factor AP-1 - metabolism
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