S‐adenosylhomocysteine sensitizes to TNF‐α hepatotoxicity in mice and liver cells: A possible etiological factor in alcoholic liver disease

In alcoholic liver disease, tumor necrosis factor‐α (TNFα) is a critical effector molecule, and abnormal methionine metabolism is a fundamental acquired metabolic abnormality. Although hepatocytes are resistant to TNFα‐induced killing under normal circumstances, previous studies have shown that prim...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2004-10, Vol.40 (4), p.989-997
Hauptverfasser:	Song, Zhenyuan, Zhou, Zhanxiang, Uriarte, Silvia, Wang, Lipeng, Kang, Y. James, Chen, Theresa, Barve, Shirish, McClain, Craig J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - pharmacology Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antineoplastic Agents - toxicity Antiseptics Biological and medical sciences Carcinoma, Hepatocellular Caspase 8 Caspases - metabolism Cell Line, Tumor Drug toxicity and drugs side effects treatment Fundamental and applied biological sciences. Psychology Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - pathology Homocysteine - pharmacology Humans Liver Diseases, Alcoholic - etiology Liver Diseases, Alcoholic - metabolism Liver Diseases, Alcoholic - pathology Liver. Bile. Biliary tracts Medical sciences Methylation - drug effects Mice Mice, Inbred C57BL NF-kappa B - metabolism Pharmacology. Drug treatments S-Adenosylhomocysteine - metabolism Toxicity: digestive system Tumor Necrosis Factor-alpha - toxicity Vertebrates: digestive system
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