Interaction of Inhibitors of the Vacuolar H+-ATPase with the Transmembrane Vo-Sector

The macrolide antibiotic concanamycin A and a designed derivative of 5-(2-indolyl)-2,4-pentadienamide (INDOL0) are potent inhibitors of vacuolar H+-ATPases, with IC50 values in the low and medium nanomolar range, respectively. Interaction of these V-ATPase inhibitors with spin-labeled subunit c in t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Easton) 2004-09, Vol.43 (38), p.12297-12305
Hauptverfasser:	Páli, Tibor, Whyteside, Graham, Dixon, Neil, Kee, Terence P, Ball, Stephen, Harrison, Michael A, Findlay, John B. C, Finbow, Malcolm E, Marsh, Derek
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Dicyclohexylcarbodiimide - analogs & derivatives Dicyclohexylcarbodiimide - metabolism Dicyclohexylcarbodiimide - pharmacology Electron Spin Resonance Spectroscopy Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Inhibitory Concentration 50 Intracellular Membranes - metabolism Macrolides - metabolism Macrolides - pharmacology Molecular Structure Nephropidae - cytology Nephropidae - enzymology Proteolipids - chemistry Proteolipids - metabolism Protons Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - enzymology Spin Labels Temperature Vacuolar Proton-Translocating ATPases - antagonists & inhibitors Vacuolar Proton-Translocating ATPases - chemistry Vacuolar Proton-Translocating ATPases - metabolism Vacuoles - enzymology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!