Fatty acid binding proteins stabilize leukotriene A4: competition with arachidonic acid but not other lipoxygenase products

Leukotriene A(4) (LTA(4)) is a chemically reactive conjugated triene epoxide product derived from 5-lipoxygenase oxygenation of arachidonic acid. At physiological pH, this reactive compound has a half-life of less than 3 s at 37 degrees C and approximately 40 s at 4 degrees C. Regardless of this aqu...

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Veröffentlicht in:	Journal of lipid research 2004-11, Vol.45 (11), p.2138
Hauptverfasser:	Zimmer, Jennifer S Dickinson, Dyckes, Douglas F, Bernlohr, David A, Murphy, Robert C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid - metabolism Binding Sites Binding, Competitive Biochemical Phenomena Biochemistry Carrier Proteins - physiology Cell Line Dose-Response Relationship, Drug Fatty Acid-Binding Proteins Hydrogen-Ion Concentration Hydroxyeicosatetraenoic Acids - pharmacology Leukotriene A4 - chemistry Leukotriene A4 - metabolism Lipoxygenase - metabolism Mass Spectrometry Models, Biological Protein Binding Rats Temperature Time Factors
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