Hypoxia-Regulated Therapeutic Gene as a Preemptive Treatment Strategy against Ischemia/Reperfusion Tissue Injury

Ischemia and reperfusion represent major mechanisms of tissue injury and organ failure. The timing of administration and the duration of action limit current treatment approaches using pharmacological agents. In this study, we have successfully developed a preemptive strategy for tissue protection u...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-08, Vol.101 (33), p.12282-12287
Hauptverfasser:	Pachori, Alok S., Melo, Luis G., Hart, Melanie L., Noiseux, Nicholas, Zhang, Lunan, Morello, Fulvio, Solomon, Scott D., Stahl, Gregory L., Pratt, Richard E., Dzau, Victor J., Braunwald, Eugene
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Animals Biological Sciences Blood Body tissues Cell Line Cytokines - genetics Gene Expression Regulation Gene therapy Genetic Therapy - methods Genetic vectors Green Fluorescent Proteins Heme Oxygenase (Decyclizing) - genetics Heme Oxygenase-1 Humans Hypoxia Hypoxia - genetics Injuries Ischemia Liver Liver - enzymology Liver - immunology Luciferases - biosynthesis Luciferases - genetics Luminescent Proteins - biosynthesis Luminescent Proteins - genetics Male Medical treatment Membrane Proteins Messenger RNA Muscle, Skeletal - enzymology Muscle, Skeletal - injuries Myocardial reperfusion Myocardial Reperfusion Injury - enzymology Myocardial Reperfusion Injury - genetics Myocardial Reperfusion Injury - therapy Physical trauma Rats Rats, Sprague-Dawley Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Reperfusion Injury - enzymology Reperfusion Injury - genetics Reperfusion Injury - therapy Tissues Transgenes
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