A phase I study of interleukin 12 with trastuzumab in patients with human epidermal growth factor receptor-2-overexpressing malignancies: analysis of sustained interferon gamma production in a subset of patients

On the basis of preclinical studies, we hypothesized that interleukin (IL)12 would potentiate the antitumor actions of an antihuman epidermal growth factor receptor-2 (HER2) monoclonal antibody (trastuzumab). We conducted a Phase I trial to determine the safety and optimal biological dose of IL-12 w...

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Veröffentlicht in:Clinical cancer research 2004-08, Vol.10 (15), p.5027
Hauptverfasser: Parihar, Robin, Nadella, Padma, Lewis, Adrian, Jensen, Rhonda, De Hoff, Carrie, Dierksheide, Julie E, VanBuskirk, Anne M, Magro, Cynthia M, Young, Donn C, Shapiro, Charles L, Carson, 3rd, William E
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Sprache:eng
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