Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by inducible and constitutive cytochrome P450 enzymes in rats

The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces tumor formation in the liver, lung, nasal cavity, and pancreas of rats. Metabolic activation is required for the tumorigenicity of this compound. The involvement of cytochrome P450 enzymes in NNK bioactiva...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1992-10, Vol.298 (1), p.279-286
Hauptverfasser:	Guo, Zuyu, Smith, Theresa J., Thomas, Paul E., Yang, Chung S.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Animals Biochemistry & Molecular Biology Biological and medical sciences Biophysics butanone Cytochrome P-450 Enzyme System - immunology Cytochrome P-450 Enzyme System - metabolism cytochrome P450 derivatives endoplasmic reticulum Enzyme Induction - drug effects Immunologic Techniques Kinetics Life Sciences & Biomedicine Lung - enzymology Medical sciences metabolism Microsomes - enzymology Microsomes, Liver - enzymology Nasal Mucosa - enzymology Nitrosamines - metabolism Rats Science & Technology Tobacco, tobacco smoking Toxicology
Online-Zugang:	Volltext
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