Combination of cassava flour cyanide and urinary thiocyanate measurements of school children in Mozambique
The maximum daily cassava flour intake of children may be calculated from determination of the total cyanide content of cassava flour and urinary thiocyanate levels of school children in samples collected at the same time and place. Four sites, two with and two without recent konzo cases, were chose...
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| Veröffentlicht in: | International journal of food sciences and nutrition 2004-05, Vol.55 (3), p.183-190 |
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| creator | Cardoso, A. Paula Ernesto, Mario Nicala, Domingos Mirione, Estevao Chavane, Leonardo N'zwalo, Hipolito Chikumba, Sergio Cliff, Julie Mabota, A. Paulo Haque, M. Rezaul Bradbury, J. Howard |
| description | The maximum daily cassava flour intake of children may be calculated from determination of the total cyanide content of cassava flour and urinary thiocyanate levels of school children in samples collected at the same time and place. Four sites, two with and two without recent konzo cases, were chosen for study. In two sites with recent konzo cases, 84% and 93% of school children consumed cassava the previous day, and the calculated maximum daily consumption of cassava was over 700 g. In two sites without recent konzo cases, about 50% of school children consumed cassava the previous day and the calculated daily consumption of cassava flour was less than 150 g. By measurements of cyanide in flour and urinary thiocyanate we are therefore able to distinguish between communities whose diet is almost totally reliant on cassava, and who are therefore susceptible to konzo, and those who have a broader diet and are free from konzo. In another calculation it is shown that 4-23% of the essential S-containing amino acids in the cassava flour consumed by children is used up to detoxify and flour cyanide to thiocyanate. This depletion of methionine and cystine may leads to protein deficiency and may contribute to onset of konzo. |
| doi_str_mv | 10.1080/09637480410001725265 |
| format | Article |
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Paula ; Ernesto, Mario ; Nicala, Domingos ; Mirione, Estevao ; Chavane, Leonardo ; N'zwalo, Hipolito ; Chikumba, Sergio ; Cliff, Julie ; Mabota, A. Paulo ; Haque, M. Rezaul ; Bradbury, J. Howard</creator><creatorcontrib>Cardoso, A. Paula ; Ernesto, Mario ; Nicala, Domingos ; Mirione, Estevao ; Chavane, Leonardo ; N'zwalo, Hipolito ; Chikumba, Sergio ; Cliff, Julie ; Mabota, A. Paulo ; Haque, M. Rezaul ; Bradbury, J. Howard</creatorcontrib><description>The maximum daily cassava flour intake of children may be calculated from determination of the total cyanide content of cassava flour and urinary thiocyanate levels of school children in samples collected at the same time and place. Four sites, two with and two without recent konzo cases, were chosen for study. In two sites with recent konzo cases, 84% and 93% of school children consumed cassava the previous day, and the calculated maximum daily consumption of cassava was over 700 g. In two sites without recent konzo cases, about 50% of school children consumed cassava the previous day and the calculated daily consumption of cassava flour was less than 150 g. By measurements of cyanide in flour and urinary thiocyanate we are therefore able to distinguish between communities whose diet is almost totally reliant on cassava, and who are therefore susceptible to konzo, and those who have a broader diet and are free from konzo. In another calculation it is shown that 4-23% of the essential S-containing amino acids in the cassava flour consumed by children is used up to detoxify and flour cyanide to thiocyanate. This depletion of methionine and cystine may leads to protein deficiency and may contribute to onset of konzo.</description><identifier>ISSN: 0963-7486</identifier><identifier>EISSN: 1465-3478</identifier><identifier>DOI: 10.1080/09637480410001725265</identifier><identifier>PMID: 15223594</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>Biological and medical sciences ; Child ; Children & youth ; Cyanides - analysis ; Cyanides - pharmacokinetics ; Cyanides - toxicity ; Diet - adverse effects ; Diet - statistics & numerical data ; Diet Surveys ; Disease Susceptibility ; Excretory system ; Feeding Behavior ; Feeding. Feeding behavior ; Flour - analysis ; Food science ; Fruits ; Fundamental and applied biological sciences. Psychology ; Humans ; Inactivation, Metabolic ; Manihot - adverse effects ; Manihot - chemistry ; Medical disorders ; Nutrition ; Paraparesis, Spastic - chemically induced ; Paraparesis, Spastic - urine ; Poverty ; Proteins ; Thiocyanates - urine ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>International journal of food sciences and nutrition, 2004-05, Vol.55 (3), p.183-190</ispartof><rights>2004 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2004</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Carfax Publishing Company May 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-7d3868754748c86ddf015d83c9bf149b6a7413b08dc92305a8f5504250ed7ae03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09637480410001725265$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09637480410001725265$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,59646,60435,61220,61401</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15897419$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15223594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cardoso, A. Paula</creatorcontrib><creatorcontrib>Ernesto, Mario</creatorcontrib><creatorcontrib>Nicala, Domingos</creatorcontrib><creatorcontrib>Mirione, Estevao</creatorcontrib><creatorcontrib>Chavane, Leonardo</creatorcontrib><creatorcontrib>N'zwalo, Hipolito</creatorcontrib><creatorcontrib>Chikumba, Sergio</creatorcontrib><creatorcontrib>Cliff, Julie</creatorcontrib><creatorcontrib>Mabota, A. Paulo</creatorcontrib><creatorcontrib>Haque, M. Rezaul</creatorcontrib><creatorcontrib>Bradbury, J. Howard</creatorcontrib><title>Combination of cassava flour cyanide and urinary thiocyanate measurements of school children in Mozambique</title><title>International journal of food sciences and nutrition</title><addtitle>Int J Food Sci Nutr</addtitle><description>The maximum daily cassava flour intake of children may be calculated from determination of the total cyanide content of cassava flour and urinary thiocyanate levels of school children in samples collected at the same time and place. Four sites, two with and two without recent konzo cases, were chosen for study. In two sites with recent konzo cases, 84% and 93% of school children consumed cassava the previous day, and the calculated maximum daily consumption of cassava was over 700 g. In two sites without recent konzo cases, about 50% of school children consumed cassava the previous day and the calculated daily consumption of cassava flour was less than 150 g. By measurements of cyanide in flour and urinary thiocyanate we are therefore able to distinguish between communities whose diet is almost totally reliant on cassava, and who are therefore susceptible to konzo, and those who have a broader diet and are free from konzo. In another calculation it is shown that 4-23% of the essential S-containing amino acids in the cassava flour consumed by children is used up to detoxify and flour cyanide to thiocyanate. This depletion of methionine and cystine may leads to protein deficiency and may contribute to onset of konzo.</description><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Children & youth</subject><subject>Cyanides - analysis</subject><subject>Cyanides - pharmacokinetics</subject><subject>Cyanides - toxicity</subject><subject>Diet - adverse effects</subject><subject>Diet - statistics & numerical data</subject><subject>Diet Surveys</subject><subject>Disease Susceptibility</subject><subject>Excretory system</subject><subject>Feeding Behavior</subject><subject>Feeding. Feeding behavior</subject><subject>Flour - analysis</subject><subject>Food science</subject><subject>Fruits</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Inactivation, Metabolic</subject><subject>Manihot - adverse effects</subject><subject>Manihot - chemistry</subject><subject>Medical disorders</subject><subject>Nutrition</subject><subject>Paraparesis, Spastic - chemically induced</subject><subject>Paraparesis, Spastic - urine</subject><subject>Poverty</subject><subject>Proteins</subject><subject>Thiocyanates - urine</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0963-7486</issn><issn>1465-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAYhEVpaDZp_0EpopCjW8mSLPmSUJZ-QUIv7dm81gfWYkuJZDdsfn1ldktaCO1JIJ6Zd2YQek3JO0oUeU_ahkmuCKeEECprUTfiGdpQ3oiKcameo82KVIVpTtFZzruVE1K-QKdU1DUTLd-g3TZOvQ8w-xhwdFhDzvATsBvjkrDeQ_DGYggGL6lgaY_nwcf1H2aLJwt5SXayYc6rOushxhHrwY8m2YB9wDfxAcqFu8W-RCcOxmxfHd9z9OPTx-_bL9X1t89ftx-uK80lnStpmGqUFLwE16oxxpXURjHd9o7ytm9Acsp6ooxua0YEKCcE4bUg1kiwhJ2jtwff2xTL2Tx3u9IllJNdTRveEi5lgfgB0inmnKzrbpOfSr-Okm7dt3tq3yJ7c_Re-smaR9Fx0AJcHAHIGkaXIGif_-BUW-K3hbs6cD64mCa4j2k03Qz7MabfIvafKJd_OQwWxnnQkOxj338a_AI9MKmK</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Cardoso, A. Paula</creator><creator>Ernesto, Mario</creator><creator>Nicala, Domingos</creator><creator>Mirione, Estevao</creator><creator>Chavane, Leonardo</creator><creator>N'zwalo, Hipolito</creator><creator>Chikumba, Sergio</creator><creator>Cliff, Julie</creator><creator>Mabota, A. Paulo</creator><creator>Haque, M. Rezaul</creator><creator>Bradbury, J. Howard</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Nature Publishing</general><general>Taylor & Francis Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>20040501</creationdate><title>Combination of cassava flour cyanide and urinary thiocyanate measurements of school children in Mozambique</title><author>Cardoso, A. Paula ; Ernesto, Mario ; Nicala, Domingos ; Mirione, Estevao ; Chavane, Leonardo ; N'zwalo, Hipolito ; Chikumba, Sergio ; Cliff, Julie ; Mabota, A. Paulo ; Haque, M. Rezaul ; Bradbury, J. Howard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-7d3868754748c86ddf015d83c9bf149b6a7413b08dc92305a8f5504250ed7ae03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Children & youth</topic><topic>Cyanides - analysis</topic><topic>Cyanides - pharmacokinetics</topic><topic>Cyanides - toxicity</topic><topic>Diet - adverse effects</topic><topic>Diet - statistics & numerical data</topic><topic>Diet Surveys</topic><topic>Disease Susceptibility</topic><topic>Excretory system</topic><topic>Feeding Behavior</topic><topic>Feeding. Feeding behavior</topic><topic>Flour - analysis</topic><topic>Food science</topic><topic>Fruits</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Inactivation, Metabolic</topic><topic>Manihot - adverse effects</topic><topic>Manihot - chemistry</topic><topic>Medical disorders</topic><topic>Nutrition</topic><topic>Paraparesis, Spastic - chemically induced</topic><topic>Paraparesis, Spastic - urine</topic><topic>Poverty</topic><topic>Proteins</topic><topic>Thiocyanates - urine</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cardoso, A. 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Paula</au><au>Ernesto, Mario</au><au>Nicala, Domingos</au><au>Mirione, Estevao</au><au>Chavane, Leonardo</au><au>N'zwalo, Hipolito</au><au>Chikumba, Sergio</au><au>Cliff, Julie</au><au>Mabota, A. Paulo</au><au>Haque, M. Rezaul</au><au>Bradbury, J. Howard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combination of cassava flour cyanide and urinary thiocyanate measurements of school children in Mozambique</atitle><jtitle>International journal of food sciences and nutrition</jtitle><addtitle>Int J Food Sci Nutr</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>55</volume><issue>3</issue><spage>183</spage><epage>190</epage><pages>183-190</pages><issn>0963-7486</issn><eissn>1465-3478</eissn><abstract>The maximum daily cassava flour intake of children may be calculated from determination of the total cyanide content of cassava flour and urinary thiocyanate levels of school children in samples collected at the same time and place. Four sites, two with and two without recent konzo cases, were chosen for study. In two sites with recent konzo cases, 84% and 93% of school children consumed cassava the previous day, and the calculated maximum daily consumption of cassava was over 700 g. In two sites without recent konzo cases, about 50% of school children consumed cassava the previous day and the calculated daily consumption of cassava flour was less than 150 g. By measurements of cyanide in flour and urinary thiocyanate we are therefore able to distinguish between communities whose diet is almost totally reliant on cassava, and who are therefore susceptible to konzo, and those who have a broader diet and are free from konzo. In another calculation it is shown that 4-23% of the essential S-containing amino acids in the cassava flour consumed by children is used up to detoxify and flour cyanide to thiocyanate. This depletion of methionine and cystine may leads to protein deficiency and may contribute to onset of konzo.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>15223594</pmid><doi>10.1080/09637480410001725265</doi><tpages>8</tpages></addata></record> |
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| ispartof | International journal of food sciences and nutrition, 2004-05, Vol.55 (3), p.183-190 |
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| source | MEDLINE; Taylor & Francis Journals Complete |
| subjects | Biological and medical sciences Child Children & youth Cyanides - analysis Cyanides - pharmacokinetics Cyanides - toxicity Diet - adverse effects Diet - statistics & numerical data Diet Surveys Disease Susceptibility Excretory system Feeding Behavior Feeding. Feeding behavior Flour - analysis Food science Fruits Fundamental and applied biological sciences. Psychology Humans Inactivation, Metabolic Manihot - adverse effects Manihot - chemistry Medical disorders Nutrition Paraparesis, Spastic - chemically induced Paraparesis, Spastic - urine Poverty Proteins Thiocyanates - urine Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Combination of cassava flour cyanide and urinary thiocyanate measurements of school children in Mozambique |
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