Mcl-1 is a novel therapeutic target for human sarcoma: Synergistic inhibition of human sarcoma xenotransplants by a combination of Mcl-1 antisense oligonucleotides with low-dose cyclophosphamide

Little is known about the role that Mcl-1, an antiapoptotic Bcl-2 family member, plays in solid tumor biology and susceptibility to anticancer therapy. We observed that the Mcl-1 protein is widely expressed in human sarcoma cell lines of different histological origin (n = 7). Because the expression...

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Veröffentlicht in:	Clinical cancer research 2004-06, Vol.10 (12), p.4185-4191
Hauptverfasser:	THALLINGER, Christiane, WOLSCHEK, Markus F, MAIERHOFER, Helmut, SKVARA, Hans, PEHAMBERGER, Hubert, MONIA, Brett P, JANSEN, Burkhard, WACHECK, Volker, SELZER, Edgar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Apoptosis Biological and medical sciences Blotting, Western Cell Line, Tumor Cyclophosphamide - therapeutic use Dose-Response Relationship, Drug Down-Regulation Drug Resistance, Neoplasm Female Humans Immunohistochemistry In Situ Nick-End Labeling Medical sciences Mice Mice, SCID Myeloid Cell Leukemia Sequence 1 Protein Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasm Transplantation Oligonucleotides - chemistry Oligonucleotides, Antisense - therapeutic use Pharmacology. Drug treatments Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Sarcoma - drug therapy Sarcoma - metabolism Staurosporine - pharmacology Time Factors Tumors
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