Parenteral iron nephrotoxicity: Potential mechanisms and consequences

Parenteral iron administration is a mainstay of anemia management in renal disease patients. However, concerns of potential iron toxicity persist. Thus, this study was conducted to more fully gauge iron toxicologic profiles and potential determinants thereof. Isolated mouse proximal tubule segments...

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Veröffentlicht in:	Kidney international 2004-07, Vol.66 (1), p.144-156
Hauptverfasser:	ZAGER, Richard A, JOHNSON, Ali C. M, HANSON, Sherry Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Cytochromes c - metabolism Dose-Response Relationship, Drug Ferric Compounds - administration & dosage Ferric Compounds - poisoning Glucaric Acid Heme Oxygenase (Decyclizing) - genetics Heme Oxygenase-1 Humans In Vitro Techniques Infusions, Parenteral Iron - administration & dosage Iron - poisoning Iron-Dextran Complex - administration & dosage Iron-Dextran Complex - poisoning Kidney - pathology Kidney - ultrastructure Kidney Cortex - enzymology Kidney Diseases - chemically induced Kidney Diseases - enzymology Kidney Diseases - pathology Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - enzymology Male Medical sciences Membrane Proteins Mice Mice, Inbred Strains Microscopy, Electron Nephrology. Urinary tract diseases RNA, Messenger - metabolism Severity of Illness Index
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