LYSOPHOSPHOLIPID RECEPTORS: Signaling and Biology
Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental cellular functions, which include proliferation, differentiation, survival, migration, adhesion, invasion, and morphogenesis. These functions...
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| Veröffentlicht in: | Annual review of biochemistry 2004-01, Vol.73 (1), p.321-354 |
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| creator | Ishii, Isao Fukushima, Nobuyuki Ye, Xiaoqin Chun, Jerold |
| description | Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine
1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect
fundamental cellular functions, which include proliferation, differentiation,
survival, migration, adhesion, invasion, and morphogenesis. These functions
influence many biological processes that include neurogenesis, angiogenesis,
wound healing, immunity, and carcinogenesis. In recent years, identification of
multiple cognate G protein-coupled receptors has provided a mechanistic
framework for understanding how LPs play such diverse roles. Generation of LP
receptor-null animals has allowed rigorous examination of receptor-mediated
physiological functions in vivo and has identified new functions for LP
receptor signaling. Efforts to develop LP receptor subtype-specific
agonists/antagonists are in progress and raise expectations for a growing
collection of chemical tools and potential therapeutic compounds. The rapidly
expanding literature on the LP receptors is herein reviewed. |
| doi_str_mv | 10.1146/annurev.biochem.73.011303.073731 |
| format | Article |
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1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect
fundamental cellular functions, which include proliferation, differentiation,
survival, migration, adhesion, invasion, and morphogenesis. These functions
influence many biological processes that include neurogenesis, angiogenesis,
wound healing, immunity, and carcinogenesis. In recent years, identification of
multiple cognate G protein-coupled receptors has provided a mechanistic
framework for understanding how LPs play such diverse roles. Generation of LP
receptor-null animals has allowed rigorous examination of receptor-mediated
physiological functions in vivo and has identified new functions for LP
receptor signaling. Efforts to develop LP receptor subtype-specific
agonists/antagonists are in progress and raise expectations for a growing
collection of chemical tools and potential therapeutic compounds. The rapidly
expanding literature on the LP receptors is herein reviewed.</description><identifier>ISSN: 0066-4154</identifier><identifier>EISSN: 1545-4509</identifier><identifier>DOI: 10.1146/annurev.biochem.73.011303.073731</identifier><identifier>PMID: 15189145</identifier><identifier>CODEN: ARBOAW</identifier><language>eng</language><publisher>Palo Alto, CA 94303-0139: Annual Reviews</publisher><subject>Animals ; Biochemistry ; Carcinogenesis ; Cardiovascular System - growth & development ; Cardiovascular System - metabolism ; Cellular biology ; Female ; G protein-coupled receptor ; Humans ; Immunity ; Ligands ; Lipids ; LPA ; lysophosphatidic acid ; lysophosphatidylcholine ; Lysophospholipids - chemistry ; Lysophospholipids - metabolism ; Mice ; Molecular Structure ; Neovascularization, Physiologic ; Nervous System - metabolism ; Ovarian Neoplasms - metabolism ; Phylogeny ; Proteins ; Rats ; Receptors, G-Protein-Coupled - classification ; Receptors, G-Protein-Coupled - genetics ; Receptors, G-Protein-Coupled - metabolism ; Receptors, Lysophospholipid ; Reproduction - physiology ; S1P ; Signal Transduction ; sphingosine 1-phosphate ; sphingosylphosphorylcholine ; Wound Healing - physiology</subject><ispartof>Annual review of biochemistry, 2004-01, Vol.73 (1), p.321-354</ispartof><rights>Copyright © 2004 by Annual Reviews. All rights reserved</rights><rights>Copyright Annual Reviews, Inc. 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a482t-5ab014c113bdbd732047bbbeb062849ca8e30b2c5390a73ab55fada75b2abcde3</citedby><cites>FETCH-LOGICAL-a482t-5ab014c113bdbd732047bbbeb062849ca8e30b2c5390a73ab55fada75b2abcde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.biochem.73.011303.073731?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.biochem.73.011303.073731$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,314,780,784,4182,27924,27925,78254,78255</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15189145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishii, Isao</creatorcontrib><creatorcontrib>Fukushima, Nobuyuki</creatorcontrib><creatorcontrib>Ye, Xiaoqin</creatorcontrib><creatorcontrib>Chun, Jerold</creatorcontrib><title>LYSOPHOSPHOLIPID RECEPTORS: Signaling and Biology</title><title>Annual review of biochemistry</title><addtitle>Annu Rev Biochem</addtitle><description>Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine
1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect
fundamental cellular functions, which include proliferation, differentiation,
survival, migration, adhesion, invasion, and morphogenesis. These functions
influence many biological processes that include neurogenesis, angiogenesis,
wound healing, immunity, and carcinogenesis. In recent years, identification of
multiple cognate G protein-coupled receptors has provided a mechanistic
framework for understanding how LPs play such diverse roles. Generation of LP
receptor-null animals has allowed rigorous examination of receptor-mediated
physiological functions in vivo and has identified new functions for LP
receptor signaling. Efforts to develop LP receptor subtype-specific
agonists/antagonists are in progress and raise expectations for a growing
collection of chemical tools and potential therapeutic compounds. The rapidly
expanding literature on the LP receptors is herein reviewed.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Carcinogenesis</subject><subject>Cardiovascular System - growth & development</subject><subject>Cardiovascular System - metabolism</subject><subject>Cellular biology</subject><subject>Female</subject><subject>G protein-coupled receptor</subject><subject>Humans</subject><subject>Immunity</subject><subject>Ligands</subject><subject>Lipids</subject><subject>LPA</subject><subject>lysophosphatidic acid</subject><subject>lysophosphatidylcholine</subject><subject>Lysophospholipids - chemistry</subject><subject>Lysophospholipids - metabolism</subject><subject>Mice</subject><subject>Molecular Structure</subject><subject>Neovascularization, Physiologic</subject><subject>Nervous System - metabolism</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Phylogeny</subject><subject>Proteins</subject><subject>Rats</subject><subject>Receptors, G-Protein-Coupled - classification</subject><subject>Receptors, G-Protein-Coupled - genetics</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Receptors, Lysophospholipid</subject><subject>Reproduction - physiology</subject><subject>S1P</subject><subject>Signal Transduction</subject><subject>sphingosine 1-phosphate</subject><subject>sphingosylphosphorylcholine</subject><subject>Wound Healing - physiology</subject><issn>0066-4154</issn><issn>1545-4509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqVkM1Kw0AURgdRbK2-ggRXbhLnN5O4Umu0hUBKUxeuhplkWlPSRGcapW_vlARcu7h8cPk493IAuEUwQIiGd7JpOqO_A1W1xYfeBZwEECECXXDCCToBY8Qo8ymD8SkYQxiGPnWbEbiwdgshJDHF52CEGIpiRNkYoPQ9zxazLHeTzhfzZ2-ZTJPFKlvm915ebRpZV83Gk03pPVVt3W4Ol-BsLWurr4acgLeXZDWd-Wn2Op8-pr6kEd77TCqIaOG-U6UqOcGQcqWUVjDEEY0LGWkCFS4YiaHkRCrG1rKUnCksVVFqMgE3PffTtF-dtnuxbTvj_rECYxJGISfUlR76UmFaa41ei09T7aQ5CATFUZkYlIlBmeBE9MpEr8whroc7ndrp8g8wOHKFpC8cUbJ2sEr_2P8f-gVwBIHo</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Ishii, Isao</creator><creator>Fukushima, Nobuyuki</creator><creator>Ye, Xiaoqin</creator><creator>Chun, Jerold</creator><general>Annual Reviews</general><general>Annual Reviews, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20040101</creationdate><title>LYSOPHOSPHOLIPID RECEPTORS: Signaling and Biology</title><author>Ishii, Isao ; Fukushima, Nobuyuki ; Ye, Xiaoqin ; Chun, Jerold</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a482t-5ab014c113bdbd732047bbbeb062849ca8e30b2c5390a73ab55fada75b2abcde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Carcinogenesis</topic><topic>Cardiovascular System - growth & development</topic><topic>Cardiovascular System - metabolism</topic><topic>Cellular biology</topic><topic>Female</topic><topic>G protein-coupled receptor</topic><topic>Humans</topic><topic>Immunity</topic><topic>Ligands</topic><topic>Lipids</topic><topic>LPA</topic><topic>lysophosphatidic acid</topic><topic>lysophosphatidylcholine</topic><topic>Lysophospholipids - chemistry</topic><topic>Lysophospholipids - metabolism</topic><topic>Mice</topic><topic>Molecular Structure</topic><topic>Neovascularization, Physiologic</topic><topic>Nervous System - metabolism</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Phylogeny</topic><topic>Proteins</topic><topic>Rats</topic><topic>Receptors, G-Protein-Coupled - classification</topic><topic>Receptors, G-Protein-Coupled - genetics</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Receptors, Lysophospholipid</topic><topic>Reproduction - physiology</topic><topic>S1P</topic><topic>Signal Transduction</topic><topic>sphingosine 1-phosphate</topic><topic>sphingosylphosphorylcholine</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishii, Isao</creatorcontrib><creatorcontrib>Fukushima, Nobuyuki</creatorcontrib><creatorcontrib>Ye, Xiaoqin</creatorcontrib><creatorcontrib>Chun, Jerold</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Annual review of biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishii, Isao</au><au>Fukushima, Nobuyuki</au><au>Ye, Xiaoqin</au><au>Chun, Jerold</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LYSOPHOSPHOLIPID RECEPTORS: Signaling and Biology</atitle><jtitle>Annual review of biochemistry</jtitle><addtitle>Annu Rev Biochem</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>73</volume><issue>1</issue><spage>321</spage><epage>354</epage><pages>321-354</pages><issn>0066-4154</issn><eissn>1545-4509</eissn><coden>ARBOAW</coden><abstract>Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine
1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect
fundamental cellular functions, which include proliferation, differentiation,
survival, migration, adhesion, invasion, and morphogenesis. These functions
influence many biological processes that include neurogenesis, angiogenesis,
wound healing, immunity, and carcinogenesis. In recent years, identification of
multiple cognate G protein-coupled receptors has provided a mechanistic
framework for understanding how LPs play such diverse roles. Generation of LP
receptor-null animals has allowed rigorous examination of receptor-mediated
physiological functions in vivo and has identified new functions for LP
receptor signaling. Efforts to develop LP receptor subtype-specific
agonists/antagonists are in progress and raise expectations for a growing
collection of chemical tools and potential therapeutic compounds. The rapidly
expanding literature on the LP receptors is herein reviewed.</abstract><cop>Palo Alto, CA 94303-0139</cop><cop>4139 El Camino Way, P.O. Box 10139</cop><cop>USA</cop><pub>Annual Reviews</pub><pmid>15189145</pmid><doi>10.1146/annurev.biochem.73.011303.073731</doi><tpages>34</tpages></addata></record> |
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| ispartof | Annual review of biochemistry, 2004-01, Vol.73 (1), p.321-354 |
| issn | 0066-4154 1545-4509 |
| language | eng |
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| source | Annual Reviews; MEDLINE |
| subjects | Animals Biochemistry Carcinogenesis Cardiovascular System - growth & development Cardiovascular System - metabolism Cellular biology Female G protein-coupled receptor Humans Immunity Ligands Lipids LPA lysophosphatidic acid lysophosphatidylcholine Lysophospholipids - chemistry Lysophospholipids - metabolism Mice Molecular Structure Neovascularization, Physiologic Nervous System - metabolism Ovarian Neoplasms - metabolism Phylogeny Proteins Rats Receptors, G-Protein-Coupled - classification Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Lysophospholipid Reproduction - physiology S1P Signal Transduction sphingosine 1-phosphate sphingosylphosphorylcholine Wound Healing - physiology |
| title | LYSOPHOSPHOLIPID RECEPTORS: Signaling and Biology |
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