Comparison of chemotherapy alone with allogeneic bone marrow transplantation in first full remission in children with acute myeloid leukemia in the AML-BFM-83 and AML-BFM-87 studies--matched pair analysis
16 patients of studies AML-BFM-83 and -87 with allogeneic bone marrow transplantation (BMT) in first complete remission (CR) were compared with matched controls with postremission chemotherapy (CT-MC). CT-MC were selected from 250 non-grafted patients with a minimum of remission duration correspondi...
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Veröffentlicht in: | Klinische Pädiatrie 1992-07, Vol.204 (4), p.246 |
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creator | Creutzig, U Bender-Götze, C Klingebiel, T Ebell, W Friedrich, W Stollmann-Gibbels, B Schmidt, H Suttorp, M Gratwohl, A Heyen, P |
description | 16 patients of studies AML-BFM-83 and -87 with allogeneic bone marrow transplantation (BMT) in first complete remission (CR) were compared with matched controls with postremission chemotherapy (CT-MC). CT-MC were selected from 250 non-grafted patients with a minimum of remission duration corresponding to the median interval between remission and allogeneic BMT (7.3 and 3.6 months in studies BFM-83 and BFM-87). Matched pair criteria according to prognostic significance were: blast cell reduction day 15 in bone marrow, FAB subtypes, white blood cell count, age, and time to CR. Therapy results in BMT and CT-MC groups were comparable: 2 relapses and 2 treatment-related deaths after BMT vs. 5 relapses. The probability for event-free interval of 9 years was: .73 (SD .12) in the BMT group vs. .67 (SD .12) in the CT-MC group. Early and late toxicity was higher in the BMT group. 3 children of the BMT group had tolerable or severe sequelae (convulsive seizures, hemiparesis). Currently, there is no advantage for allogeneic BMT in first CR according to our results. Only high risk patients should be grafted as soon as possible after achieving CR. |
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CT-MC were selected from 250 non-grafted patients with a minimum of remission duration corresponding to the median interval between remission and allogeneic BMT (7.3 and 3.6 months in studies BFM-83 and BFM-87). Matched pair criteria according to prognostic significance were: blast cell reduction day 15 in bone marrow, FAB subtypes, white blood cell count, age, and time to CR. Therapy results in BMT and CT-MC groups were comparable: 2 relapses and 2 treatment-related deaths after BMT vs. 5 relapses. The probability for event-free interval of 9 years was: .73 (SD .12) in the BMT group vs. .67 (SD .12) in the CT-MC group. Early and late toxicity was higher in the BMT group. 3 children of the BMT group had tolerable or severe sequelae (convulsive seizures, hemiparesis). Currently, there is no advantage for allogeneic BMT in first CR according to our results. Only high risk patients should be grafted as soon as possible after achieving CR.</description><identifier>ISSN: 0300-8630</identifier><identifier>PMID: 1518260</identifier><language>ger</language><publisher>Germany</publisher><subject>Adolescent ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Bone Marrow Transplantation ; Child ; Child, Preschool ; Combined Modality Therapy ; Cranial Irradiation ; Female ; Follow-Up Studies ; Graft vs Host Disease - mortality ; Humans ; Infant ; Leukemia, Myeloid, Acute - mortality ; Leukemia, Myeloid, Acute - therapy ; Male ; Matched-Pair Analysis ; Remission Induction ; Survival Rate</subject><ispartof>Klinische Pädiatrie, 1992-07, Vol.204 (4), p.246</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1518260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Creutzig, U</creatorcontrib><creatorcontrib>Bender-Götze, C</creatorcontrib><creatorcontrib>Klingebiel, T</creatorcontrib><creatorcontrib>Ebell, W</creatorcontrib><creatorcontrib>Friedrich, W</creatorcontrib><creatorcontrib>Stollmann-Gibbels, B</creatorcontrib><creatorcontrib>Schmidt, H</creatorcontrib><creatorcontrib>Suttorp, M</creatorcontrib><creatorcontrib>Gratwohl, A</creatorcontrib><creatorcontrib>Heyen, P</creatorcontrib><title>Comparison of chemotherapy alone with allogeneic bone marrow transplantation in first full remission in children with acute myeloid leukemia in the AML-BFM-83 and AML-BFM-87 studies--matched pair analysis</title><title>Klinische Pädiatrie</title><addtitle>Klin Padiatr</addtitle><description>16 patients of studies AML-BFM-83 and -87 with allogeneic bone marrow transplantation (BMT) in first complete remission (CR) were compared with matched controls with postremission chemotherapy (CT-MC). CT-MC were selected from 250 non-grafted patients with a minimum of remission duration corresponding to the median interval between remission and allogeneic BMT (7.3 and 3.6 months in studies BFM-83 and BFM-87). Matched pair criteria according to prognostic significance were: blast cell reduction day 15 in bone marrow, FAB subtypes, white blood cell count, age, and time to CR. Therapy results in BMT and CT-MC groups were comparable: 2 relapses and 2 treatment-related deaths after BMT vs. 5 relapses. The probability for event-free interval of 9 years was: .73 (SD .12) in the BMT group vs. .67 (SD .12) in the CT-MC group. Early and late toxicity was higher in the BMT group. 3 children of the BMT group had tolerable or severe sequelae (convulsive seizures, hemiparesis). Currently, there is no advantage for allogeneic BMT in first CR according to our results. Only high risk patients should be grafted as soon as possible after achieving CR.</description><subject>Adolescent</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Bone Marrow Transplantation</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Combined Modality Therapy</subject><subject>Cranial Irradiation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Graft vs Host Disease - mortality</subject><subject>Humans</subject><subject>Infant</subject><subject>Leukemia, Myeloid, Acute - mortality</subject><subject>Leukemia, Myeloid, Acute - therapy</subject><subject>Male</subject><subject>Matched-Pair Analysis</subject><subject>Remission Induction</subject><subject>Survival Rate</subject><issn>0300-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1OwzAQhbMAlVI4ApIvYMmum8RZlooCUis23VcT_xCDY0e2oyp35FC4IhKrmXl6-ubp3RRLwgjBvGLkrriP8YsQumlIsygWtKR8XZFl8bPz_QDBRO-Q10h0qvepUwGGCYH1TqGLSV1erf9UThmB2qvYQwj-glIAFwcLLkEymWAc0ibEhPRoLQqqNzHOuuiMlUG5mSfGlCmTst5IZNX4nb1w9eXnaHs84Of9EXOGwMn_s0YxjdKoiHEPKWeVaAATsgnsFE18KG412Kge57kqTvuX0-4NHz5e33fbAx5KRrCWrZS6KlnF11xwoXMTZVtT3dQMOKUtaxotuKIbXre6pu262ghZay0JEGgoWxVPf9hhbHslz0MwuY_pPJfKfgGkFHYf</recordid><startdate>199207</startdate><enddate>199207</enddate><creator>Creutzig, U</creator><creator>Bender-Götze, C</creator><creator>Klingebiel, T</creator><creator>Ebell, W</creator><creator>Friedrich, W</creator><creator>Stollmann-Gibbels, B</creator><creator>Schmidt, H</creator><creator>Suttorp, M</creator><creator>Gratwohl, A</creator><creator>Heyen, P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>199207</creationdate><title>Comparison of chemotherapy alone with allogeneic bone marrow transplantation in first full remission in children with acute myeloid leukemia in the AML-BFM-83 and AML-BFM-87 studies--matched pair analysis</title><author>Creutzig, U ; Bender-Götze, C ; Klingebiel, T ; Ebell, W ; Friedrich, W ; Stollmann-Gibbels, B ; Schmidt, H ; Suttorp, M ; Gratwohl, A ; Heyen, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p530-fdbddf6536828c8cf8265b71f973a811b399fc8e1487bf71b264cd7ffd0a0a913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>ger</language><creationdate>1992</creationdate><topic>Adolescent</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Bone Marrow Transplantation</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Combined Modality Therapy</topic><topic>Cranial Irradiation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Graft vs Host Disease - mortality</topic><topic>Humans</topic><topic>Infant</topic><topic>Leukemia, Myeloid, Acute - mortality</topic><topic>Leukemia, Myeloid, Acute - therapy</topic><topic>Male</topic><topic>Matched-Pair Analysis</topic><topic>Remission Induction</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Creutzig, U</creatorcontrib><creatorcontrib>Bender-Götze, C</creatorcontrib><creatorcontrib>Klingebiel, T</creatorcontrib><creatorcontrib>Ebell, W</creatorcontrib><creatorcontrib>Friedrich, W</creatorcontrib><creatorcontrib>Stollmann-Gibbels, B</creatorcontrib><creatorcontrib>Schmidt, H</creatorcontrib><creatorcontrib>Suttorp, M</creatorcontrib><creatorcontrib>Gratwohl, A</creatorcontrib><creatorcontrib>Heyen, P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Klinische Pädiatrie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Creutzig, U</au><au>Bender-Götze, C</au><au>Klingebiel, T</au><au>Ebell, W</au><au>Friedrich, W</au><au>Stollmann-Gibbels, B</au><au>Schmidt, H</au><au>Suttorp, M</au><au>Gratwohl, A</au><au>Heyen, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of chemotherapy alone with allogeneic bone marrow transplantation in first full remission in children with acute myeloid leukemia in the AML-BFM-83 and AML-BFM-87 studies--matched pair analysis</atitle><jtitle>Klinische Pädiatrie</jtitle><addtitle>Klin Padiatr</addtitle><date>1992-07</date><risdate>1992</risdate><volume>204</volume><issue>4</issue><spage>246</spage><pages>246-</pages><issn>0300-8630</issn><abstract>16 patients of studies AML-BFM-83 and -87 with allogeneic bone marrow transplantation (BMT) in first complete remission (CR) were compared with matched controls with postremission chemotherapy (CT-MC). CT-MC were selected from 250 non-grafted patients with a minimum of remission duration corresponding to the median interval between remission and allogeneic BMT (7.3 and 3.6 months in studies BFM-83 and BFM-87). Matched pair criteria according to prognostic significance were: blast cell reduction day 15 in bone marrow, FAB subtypes, white blood cell count, age, and time to CR. Therapy results in BMT and CT-MC groups were comparable: 2 relapses and 2 treatment-related deaths after BMT vs. 5 relapses. The probability for event-free interval of 9 years was: .73 (SD .12) in the BMT group vs. .67 (SD .12) in the CT-MC group. Early and late toxicity was higher in the BMT group. 3 children of the BMT group had tolerable or severe sequelae (convulsive seizures, hemiparesis). Currently, there is no advantage for allogeneic BMT in first CR according to our results. Only high risk patients should be grafted as soon as possible after achieving CR.</abstract><cop>Germany</cop><pmid>1518260</pmid></addata></record> |
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source | MEDLINE; Thieme Connect Journals |
subjects | Adolescent Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bone Marrow Transplantation Child Child, Preschool Combined Modality Therapy Cranial Irradiation Female Follow-Up Studies Graft vs Host Disease - mortality Humans Infant Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - therapy Male Matched-Pair Analysis Remission Induction Survival Rate |
title | Comparison of chemotherapy alone with allogeneic bone marrow transplantation in first full remission in children with acute myeloid leukemia in the AML-BFM-83 and AML-BFM-87 studies--matched pair analysis |
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