Chemotactic Activities of Peripheral Blood Polymorphonuclear Leukocytes and Peritoneal Exudate Polymorphonuclear Leukocytes in MRL Mice
Abstract Chemotactic responsiveness to fMet-Leu-Phe in concentrations of 10−8 to 10−4M in the Boyden chamber was compared between peritoneal exudate cells (PEC) and polymorphonuclear leukocytes (PMN) isolated from peripheral blood, between MRL/Mp-+/+ (MRL-+/+) and MRL/Mp-1pr/1pr (MRL-1pr/1pr) mice,...
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| Veröffentlicht in: | Immunopharmacology and immunotoxicology 1992, Vol.14 (3), p.625-635 |
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| container_title | Immunopharmacology and immunotoxicology |
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| creator | Sasagawa, Sumiko Satow, Yukio Suzuki, Kazuo Hosokawa, Tomokazu |
| description | Abstract
Chemotactic responsiveness to fMet-Leu-Phe in concentrations of 10−8 to 10−4M in the Boyden chamber was compared between peritoneal exudate cells (PEC) and polymorphonuclear leukocytes (PMN) isolated from peripheral blood, between MRL/Mp-+/+ (MRL-+/+) and MRL/Mp-1pr/1pr (MRL-1pr/1pr) mice, and between young (6 - 9 week old) and aged (16 - 24 week old) mice. Chemotactic responsiveness of PEC did not differ between MRL-+/+ and MRL-1pr/1pr, and young and aged mice. While, PMN showed greater chemotaxis in aged MRL-+/+ mice than that in aged MRL-1pr/1pr mice. These results suggest that chemotactic responsiveness of PMN differ from that of PEC which is assumed to be preactivated by an inflammatory agent injected into the peritoneal cavity to elicit cells. Less responsiveness of PMN to the bacterial origin peptide might relate to the autoimmune disease of this murine model. |
| doi_str_mv | 10.3109/08923979209005414 |
| format | Article |
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Chemotactic responsiveness to fMet-Leu-Phe in concentrations of 10−8 to 10−4M in the Boyden chamber was compared between peritoneal exudate cells (PEC) and polymorphonuclear leukocytes (PMN) isolated from peripheral blood, between MRL/Mp-+/+ (MRL-+/+) and MRL/Mp-1pr/1pr (MRL-1pr/1pr) mice, and between young (6 - 9 week old) and aged (16 - 24 week old) mice. Chemotactic responsiveness of PEC did not differ between MRL-+/+ and MRL-1pr/1pr, and young and aged mice. While, PMN showed greater chemotaxis in aged MRL-+/+ mice than that in aged MRL-1pr/1pr mice. These results suggest that chemotactic responsiveness of PMN differ from that of PEC which is assumed to be preactivated by an inflammatory agent injected into the peritoneal cavity to elicit cells. Less responsiveness of PMN to the bacterial origin peptide might relate to the autoimmune disease of this murine model.</description><identifier>ISSN: 0892-3973</identifier><identifier>EISSN: 1532-2513</identifier><identifier>DOI: 10.3109/08923979209005414</identifier><identifier>PMID: 1517536</identifier><identifier>CODEN: IITOEF</identifier><language>eng</language><publisher>Monticello, NY: Informa UK Ltd</publisher><subject>Amino Acid Sequence ; Animals ; Autoimmune Diseases - genetics ; Autoimmune Diseases - immunology ; Biological and medical sciences ; Cell physiology ; Chemotaxis, Leukocyte ; Fundamental and applied biological sciences. Psychology ; Mice ; Mice, Mutant Strains ; Molecular and cellular biology ; Molecular Sequence Data ; Motility and taxis ; N-Formylmethionine Leucyl-Phenylalanine - chemistry ; N-Formylmethionine Leucyl-Phenylalanine - pharmacology ; Neutrophils - immunology ; Peritoneal Cavity - cytology</subject><ispartof>Immunopharmacology and immunotoxicology, 1992, Vol.14 (3), p.625-635</ispartof><rights>1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1992</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-a74cf19c500690b4d0d2b30bcb6bc38f8cda9a0bc4b4bf1a4a9d404d04c6fafc3</citedby><cites>FETCH-LOGICAL-c430t-a74cf19c500690b4d0d2b30bcb6bc38f8cda9a0bc4b4bf1a4a9d404d04c6fafc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/08923979209005414$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/08923979209005414$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4603282$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1517536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sasagawa, Sumiko</creatorcontrib><creatorcontrib>Satow, Yukio</creatorcontrib><creatorcontrib>Suzuki, Kazuo</creatorcontrib><creatorcontrib>Hosokawa, Tomokazu</creatorcontrib><title>Chemotactic Activities of Peripheral Blood Polymorphonuclear Leukocytes and Peritoneal Exudate Polymorphonuclear Leukocytes in MRL Mice</title><title>Immunopharmacology and immunotoxicology</title><addtitle>Immunopharmacol Immunotoxicol</addtitle><description>Abstract
Chemotactic responsiveness to fMet-Leu-Phe in concentrations of 10−8 to 10−4M in the Boyden chamber was compared between peritoneal exudate cells (PEC) and polymorphonuclear leukocytes (PMN) isolated from peripheral blood, between MRL/Mp-+/+ (MRL-+/+) and MRL/Mp-1pr/1pr (MRL-1pr/1pr) mice, and between young (6 - 9 week old) and aged (16 - 24 week old) mice. Chemotactic responsiveness of PEC did not differ between MRL-+/+ and MRL-1pr/1pr, and young and aged mice. While, PMN showed greater chemotaxis in aged MRL-+/+ mice than that in aged MRL-1pr/1pr mice. These results suggest that chemotactic responsiveness of PMN differ from that of PEC which is assumed to be preactivated by an inflammatory agent injected into the peritoneal cavity to elicit cells. Less responsiveness of PMN to the bacterial origin peptide might relate to the autoimmune disease of this murine model.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Autoimmune Diseases - genetics</subject><subject>Autoimmune Diseases - immunology</subject><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Chemotaxis, Leukocyte</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>Motility and taxis</subject><subject>N-Formylmethionine Leucyl-Phenylalanine - chemistry</subject><subject>N-Formylmethionine Leucyl-Phenylalanine - pharmacology</subject><subject>Neutrophils - immunology</subject><subject>Peritoneal Cavity - cytology</subject><issn>0892-3973</issn><issn>1532-2513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1DAUhi0EKsPAA7BAygKxCz2OnWQs2LSjcpGmokKwjk58UVyceLAdYJ6A167LDKCq0mxsWf_3Hdm_CXlO4TWjIE5hJSomWlGBAKg55Q_IgtasKquasodkcZuXGWCPyZMYrwGoaKE-ISe0pm3NmgX5vR706BPKZGVxltcfNlkdC2-KKx3sdtABXXHuvFfFlXe70Yft4KdZOo2h2Oj5m5e7lAWc1B8j-Uln4-LXrDDp446disvPm-LSSv2UPDLoon522Jfk67uLL-sP5ebT-4_rs00pOYNUYsuloULWAI2AnitQVc-gl33TS7YyK6lQYD7znveGIkehOGSMy8agkWxJXu3nboP_PuuYutFGqZ3DSfs5di2jnLW5sSWhe1AGH2PQptsGO2LYdRS62_K7e-Vn58Vh-NyPWv039m3n_OUhxyjRmYCTtPEfxhtg1arK2Ns9Zifjw4g_fXCqS7hzPvx12LFbvLmjD_k_0iAx6O7az2HK9R55ww2_irU3</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Sasagawa, Sumiko</creator><creator>Satow, Yukio</creator><creator>Suzuki, Kazuo</creator><creator>Hosokawa, Tomokazu</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Chemotactic Activities of Peripheral Blood Polymorphonuclear Leukocytes and Peritoneal Exudate Polymorphonuclear Leukocytes in MRL Mice</title><author>Sasagawa, Sumiko ; Satow, Yukio ; Suzuki, Kazuo ; Hosokawa, Tomokazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-a74cf19c500690b4d0d2b30bcb6bc38f8cda9a0bc4b4bf1a4a9d404d04c6fafc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Autoimmune Diseases - genetics</topic><topic>Autoimmune Diseases - immunology</topic><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Chemotaxis, Leukocyte</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Motility and taxis</topic><topic>N-Formylmethionine Leucyl-Phenylalanine - chemistry</topic><topic>N-Formylmethionine Leucyl-Phenylalanine - pharmacology</topic><topic>Neutrophils - immunology</topic><topic>Peritoneal Cavity - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sasagawa, Sumiko</creatorcontrib><creatorcontrib>Satow, Yukio</creatorcontrib><creatorcontrib>Suzuki, Kazuo</creatorcontrib><creatorcontrib>Hosokawa, Tomokazu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunopharmacology and immunotoxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sasagawa, Sumiko</au><au>Satow, Yukio</au><au>Suzuki, Kazuo</au><au>Hosokawa, Tomokazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemotactic Activities of Peripheral Blood Polymorphonuclear Leukocytes and Peritoneal Exudate Polymorphonuclear Leukocytes in MRL Mice</atitle><jtitle>Immunopharmacology and immunotoxicology</jtitle><addtitle>Immunopharmacol Immunotoxicol</addtitle><date>1992</date><risdate>1992</risdate><volume>14</volume><issue>3</issue><spage>625</spage><epage>635</epage><pages>625-635</pages><issn>0892-3973</issn><eissn>1532-2513</eissn><coden>IITOEF</coden><abstract>Abstract
Chemotactic responsiveness to fMet-Leu-Phe in concentrations of 10−8 to 10−4M in the Boyden chamber was compared between peritoneal exudate cells (PEC) and polymorphonuclear leukocytes (PMN) isolated from peripheral blood, between MRL/Mp-+/+ (MRL-+/+) and MRL/Mp-1pr/1pr (MRL-1pr/1pr) mice, and between young (6 - 9 week old) and aged (16 - 24 week old) mice. Chemotactic responsiveness of PEC did not differ between MRL-+/+ and MRL-1pr/1pr, and young and aged mice. While, PMN showed greater chemotaxis in aged MRL-+/+ mice than that in aged MRL-1pr/1pr mice. These results suggest that chemotactic responsiveness of PMN differ from that of PEC which is assumed to be preactivated by an inflammatory agent injected into the peritoneal cavity to elicit cells. Less responsiveness of PMN to the bacterial origin peptide might relate to the autoimmune disease of this murine model.</abstract><cop>Monticello, NY</cop><pub>Informa UK Ltd</pub><pmid>1517536</pmid><doi>10.3109/08923979209005414</doi><tpages>11</tpages></addata></record> |
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| ispartof | Immunopharmacology and immunotoxicology, 1992, Vol.14 (3), p.625-635 |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Amino Acid Sequence Animals Autoimmune Diseases - genetics Autoimmune Diseases - immunology Biological and medical sciences Cell physiology Chemotaxis, Leukocyte Fundamental and applied biological sciences. Psychology Mice Mice, Mutant Strains Molecular and cellular biology Molecular Sequence Data Motility and taxis N-Formylmethionine Leucyl-Phenylalanine - chemistry N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils - immunology Peritoneal Cavity - cytology |
| title | Chemotactic Activities of Peripheral Blood Polymorphonuclear Leukocytes and Peritoneal Exudate Polymorphonuclear Leukocytes in MRL Mice |
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