new antimalarial quassinoid from Simaba orinocensis

A new antimalarial quassinoid, namely, orinocinolide (1), was isolated from the root bark of Simaba orinocensis, together with the previously reported simalikalactone D (2). The structure of 1 was determined primarily from 1D and 2D NMR analysis, as well as by chemical derivatization. Compound 1 was...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2004-05, Vol.67 (5), p.772-777
Hauptverfasser:	Muhammad, I, Bedir, E, Khan, S.I, Tekwani, B.L, Khan, I.A, Takamatsu, S, Pelletier, J, Walker, L.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Drug Screening Assays, Antitumor General pharmacology Humans Inhibitory Concentration 50 Medical sciences Molecular Structure Peru Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Plasmodium falciparum - drug effects Quassins - chemistry Quassins - isolation & purification Quassins - pharmacology Simaroubaceae - chemistry Tumor Cells, Cultured
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