Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina
Summary Adipose tissue is a secretory organ producing a variety of bioactive substances, such as adiponectin. Adiponectin has antiatherogenic properties while plasminogen activator inhibitor type 1 (PAI-1) is closely involved in the development of atherosclerosis. The relationship between adiponecti...
Gespeichert in:
| Veröffentlicht in: | Thrombosis and haemostasis 2004-05, Vol.91 (5), p.1026-1030 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1030 |
|---|---|
| container_issue | 5 |
| container_start_page | 1026 |
| container_title | Thrombosis and haemostasis |
| container_volume | 91 |
| creator | Maruyoshi, Hidetomo Kojima, Sunao Funahashi, Tohru Miyamoto, Shinzo Hokamaki, Jun Soejima, Hirofumi Sakamoto, Tomohiro Kawano, Hiroaki Yoshimura, Michihiro Kitagawa, Akira Matsuzawa, Yuji Ogawa, Hisao |
| description | Summary
Adipose tissue is a secretory organ producing a variety of bioactive substances, such as adiponectin. Adiponectin has antiatherogenic properties while plasminogen activator inhibitor type 1 (PAI-1) is closely involved in the development of atherosclerosis. The relationship between adiponectin and PAI-1 in patients with coronary artery disease (CAD) has not been clarified. This study examined plasma levels of adiponectin and PAI-1 in 64 patients with stable exertional angina (SEA) and 65 patients with the chest pain syndrome (CPS). Plasma logadiponectin levels were significantly lower in patients with SEA (0.62±0.08 µg/dL) compared to those with CPS (0.86± 0.05 µg/dL) (p |
| doi_str_mv | 10.1160/TH03-12-0731 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_15116265</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71887673</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4281-8300f87c0c05610ae0f1b35f515857d3fe271963b2421ec2d991f3622586a0b93</originalsourceid><addsrcrecordid>eNqtkEtv1DAURiMEokNhxxp5xYYG_IjtZFlVpUWqxKZI7CzHuWlcJXbwdabMvyfRjEBCYsfKD537fbqnKN4y-pExRT_d31JRMl5SLdizYsel0qWqm-_Pix0VFS0Vr-RZ8QrxkVKmqka-LM6YXEe5krsiX3Z-jgFc9oF4JD7sISGMB5JgtBk6kiOZR4uTD_EBArErubc5phUdfOu3Wz7MQNj6QWabPYSM5MnngWC27QgEfkLKPgY7EhsefLCvixe9HRHenM7z4tvn6_ur2_Lu682Xq8u70lW8ZmUtKO1r7aijUjFqgfasFbKXTNZSd6IHrlmjRMsrzsDxrmlYLxTnslaWto04L94fc-cUfyyA2UweHYyjDRAXNJrVtVZarODFEXQpIibozZz8ZNPBMGo2y2azbBg3m-UVf3fKXdoJuj_wSesKfDgCefAwgXmMS1rXx3_FuSONbrA52wXS78g8pDi1ET0aGzozWJjiqnV7uxjy5trY5Aa_B-MRFzA4g_N2NJMNC7rk52yElnRt8f-xRWv9d4PBIT6ZIU-j-AUAutdO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71887673</pqid></control><display><type>article</type><title>Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina</title><source>MEDLINE</source><source>Thieme Connect Journals</source><creator>Maruyoshi, Hidetomo ; Kojima, Sunao ; Funahashi, Tohru ; Miyamoto, Shinzo ; Hokamaki, Jun ; Soejima, Hirofumi ; Sakamoto, Tomohiro ; Kawano, Hiroaki ; Yoshimura, Michihiro ; Kitagawa, Akira ; Matsuzawa, Yuji ; Ogawa, Hisao</creator><creatorcontrib>Maruyoshi, Hidetomo ; Kojima, Sunao ; Funahashi, Tohru ; Miyamoto, Shinzo ; Hokamaki, Jun ; Soejima, Hirofumi ; Sakamoto, Tomohiro ; Kawano, Hiroaki ; Yoshimura, Michihiro ; Kitagawa, Akira ; Matsuzawa, Yuji ; Ogawa, Hisao</creatorcontrib><description>Summary
Adipose tissue is a secretory organ producing a variety of bioactive substances, such as adiponectin. Adiponectin has antiatherogenic properties while plasminogen activator inhibitor type 1 (PAI-1) is closely involved in the development of atherosclerosis. The relationship between adiponectin and PAI-1 in patients with coronary artery disease (CAD) has not been clarified. This study examined plasma levels of adiponectin and PAI-1 in 64 patients with stable exertional angina (SEA) and 65 patients with the chest pain syndrome (CPS). Plasma logadiponectin levels were significantly lower in patients with SEA (0.62±0.08 µg/dL) compared to those with CPS (0.86± 0.05 µg/dL) (p<0.0001). The plasma levels of log-PAI-1 were significantly higher in patients with SEA (1.23±0.18 ng/mL) compared to those with CPS (1.15±0.22 ng/mL) (p<0.05). Plasma log-adiponectin levels correlated negatively with diabetes mellitus (DM), body mass index (BMI), log-PAI-1 (r=−0.284, p<0.001), triglyceride (TG), and remnant-like particles cholesterol (RLP-C), and positively with high-density lipoprotein cholesterol (HDL-C) levels. Plasma levels of log-PAI-1 correlated positively with DM, BMI, TG and RLP-C levels, and negatively with HDL-C levels. Multiple logistic regression analysis identified sex, angina pectoris, and PAI-1 as independent determinants of hyperadiponectinemia (p<0.05). Adiponectin is inversely related to PAI-1. DM, BMI, TG, HDL-C, and RLP-C are common mediators between adiponectin and PAI-1, and treatment for common mediators may prevent the development of CAD by reducing PAI-1 and increasing adiponectin levels.</description><identifier>ISSN: 0340-6245</identifier><identifier>EISSN: 2567-689X</identifier><identifier>DOI: 10.1160/TH03-12-0731</identifier><identifier>PMID: 15116265</identifier><language>eng</language><publisher>Germany: Schattauer Verlag für Medizin und Naturwissenschaften</publisher><subject>Adiponectin ; Adult ; Aged ; Aged, 80 and over ; Angina Pectoris - blood ; Cell Signaling and Vessel Remodeling ; Chest Pain - blood ; Diabetes Mellitus - blood ; Female ; Humans ; Intercellular Signaling Peptides and Proteins - analysis ; Logistic Models ; Male ; Middle Aged ; Plasminogen Activator Inhibitor 1 - blood ; Sex Factors</subject><ispartof>Thrombosis and haemostasis, 2004-05, Vol.91 (5), p.1026-1030</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4281-8300f87c0c05610ae0f1b35f515857d3fe271963b2421ec2d991f3622586a0b93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH03-12-0731.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1160/TH03-12-0731$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3005,27901,27902,54534,54535</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15116265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maruyoshi, Hidetomo</creatorcontrib><creatorcontrib>Kojima, Sunao</creatorcontrib><creatorcontrib>Funahashi, Tohru</creatorcontrib><creatorcontrib>Miyamoto, Shinzo</creatorcontrib><creatorcontrib>Hokamaki, Jun</creatorcontrib><creatorcontrib>Soejima, Hirofumi</creatorcontrib><creatorcontrib>Sakamoto, Tomohiro</creatorcontrib><creatorcontrib>Kawano, Hiroaki</creatorcontrib><creatorcontrib>Yoshimura, Michihiro</creatorcontrib><creatorcontrib>Kitagawa, Akira</creatorcontrib><creatorcontrib>Matsuzawa, Yuji</creatorcontrib><creatorcontrib>Ogawa, Hisao</creatorcontrib><title>Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina</title><title>Thrombosis and haemostasis</title><addtitle>Thromb Haemost</addtitle><description>Summary
Adipose tissue is a secretory organ producing a variety of bioactive substances, such as adiponectin. Adiponectin has antiatherogenic properties while plasminogen activator inhibitor type 1 (PAI-1) is closely involved in the development of atherosclerosis. The relationship between adiponectin and PAI-1 in patients with coronary artery disease (CAD) has not been clarified. This study examined plasma levels of adiponectin and PAI-1 in 64 patients with stable exertional angina (SEA) and 65 patients with the chest pain syndrome (CPS). Plasma logadiponectin levels were significantly lower in patients with SEA (0.62±0.08 µg/dL) compared to those with CPS (0.86± 0.05 µg/dL) (p<0.0001). The plasma levels of log-PAI-1 were significantly higher in patients with SEA (1.23±0.18 ng/mL) compared to those with CPS (1.15±0.22 ng/mL) (p<0.05). Plasma log-adiponectin levels correlated negatively with diabetes mellitus (DM), body mass index (BMI), log-PAI-1 (r=−0.284, p<0.001), triglyceride (TG), and remnant-like particles cholesterol (RLP-C), and positively with high-density lipoprotein cholesterol (HDL-C) levels. Plasma levels of log-PAI-1 correlated positively with DM, BMI, TG and RLP-C levels, and negatively with HDL-C levels. Multiple logistic regression analysis identified sex, angina pectoris, and PAI-1 as independent determinants of hyperadiponectinemia (p<0.05). Adiponectin is inversely related to PAI-1. DM, BMI, TG, HDL-C, and RLP-C are common mediators between adiponectin and PAI-1, and treatment for common mediators may prevent the development of CAD by reducing PAI-1 and increasing adiponectin levels.</description><subject>Adiponectin</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angina Pectoris - blood</subject><subject>Cell Signaling and Vessel Remodeling</subject><subject>Chest Pain - blood</subject><subject>Diabetes Mellitus - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - analysis</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Plasminogen Activator Inhibitor 1 - blood</subject><subject>Sex Factors</subject><issn>0340-6245</issn><issn>2567-689X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqtkEtv1DAURiMEokNhxxp5xYYG_IjtZFlVpUWqxKZI7CzHuWlcJXbwdabMvyfRjEBCYsfKD537fbqnKN4y-pExRT_d31JRMl5SLdizYsel0qWqm-_Pix0VFS0Vr-RZ8QrxkVKmqka-LM6YXEe5krsiX3Z-jgFc9oF4JD7sISGMB5JgtBk6kiOZR4uTD_EBArErubc5phUdfOu3Wz7MQNj6QWabPYSM5MnngWC27QgEfkLKPgY7EhsefLCvixe9HRHenM7z4tvn6_ur2_Lu682Xq8u70lW8ZmUtKO1r7aijUjFqgfasFbKXTNZSd6IHrlmjRMsrzsDxrmlYLxTnslaWto04L94fc-cUfyyA2UweHYyjDRAXNJrVtVZarODFEXQpIibozZz8ZNPBMGo2y2azbBg3m-UVf3fKXdoJuj_wSesKfDgCefAwgXmMS1rXx3_FuSONbrA52wXS78g8pDi1ET0aGzozWJjiqnV7uxjy5trY5Aa_B-MRFzA4g_N2NJMNC7rk52yElnRt8f-xRWv9d4PBIT6ZIU-j-AUAutdO</recordid><startdate>200405</startdate><enddate>200405</enddate><creator>Maruyoshi, Hidetomo</creator><creator>Kojima, Sunao</creator><creator>Funahashi, Tohru</creator><creator>Miyamoto, Shinzo</creator><creator>Hokamaki, Jun</creator><creator>Soejima, Hirofumi</creator><creator>Sakamoto, Tomohiro</creator><creator>Kawano, Hiroaki</creator><creator>Yoshimura, Michihiro</creator><creator>Kitagawa, Akira</creator><creator>Matsuzawa, Yuji</creator><creator>Ogawa, Hisao</creator><general>Schattauer Verlag für Medizin und Naturwissenschaften</general><general>Schattauer GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200405</creationdate><title>Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina</title><author>Maruyoshi, Hidetomo ; Kojima, Sunao ; Funahashi, Tohru ; Miyamoto, Shinzo ; Hokamaki, Jun ; Soejima, Hirofumi ; Sakamoto, Tomohiro ; Kawano, Hiroaki ; Yoshimura, Michihiro ; Kitagawa, Akira ; Matsuzawa, Yuji ; Ogawa, Hisao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4281-8300f87c0c05610ae0f1b35f515857d3fe271963b2421ec2d991f3622586a0b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adiponectin</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angina Pectoris - blood</topic><topic>Cell Signaling and Vessel Remodeling</topic><topic>Chest Pain - blood</topic><topic>Diabetes Mellitus - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - analysis</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Plasminogen Activator Inhibitor 1 - blood</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maruyoshi, Hidetomo</creatorcontrib><creatorcontrib>Kojima, Sunao</creatorcontrib><creatorcontrib>Funahashi, Tohru</creatorcontrib><creatorcontrib>Miyamoto, Shinzo</creatorcontrib><creatorcontrib>Hokamaki, Jun</creatorcontrib><creatorcontrib>Soejima, Hirofumi</creatorcontrib><creatorcontrib>Sakamoto, Tomohiro</creatorcontrib><creatorcontrib>Kawano, Hiroaki</creatorcontrib><creatorcontrib>Yoshimura, Michihiro</creatorcontrib><creatorcontrib>Kitagawa, Akira</creatorcontrib><creatorcontrib>Matsuzawa, Yuji</creatorcontrib><creatorcontrib>Ogawa, Hisao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maruyoshi, Hidetomo</au><au>Kojima, Sunao</au><au>Funahashi, Tohru</au><au>Miyamoto, Shinzo</au><au>Hokamaki, Jun</au><au>Soejima, Hirofumi</au><au>Sakamoto, Tomohiro</au><au>Kawano, Hiroaki</au><au>Yoshimura, Michihiro</au><au>Kitagawa, Akira</au><au>Matsuzawa, Yuji</au><au>Ogawa, Hisao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina</atitle><jtitle>Thrombosis and haemostasis</jtitle><addtitle>Thromb Haemost</addtitle><date>2004-05</date><risdate>2004</risdate><volume>91</volume><issue>5</issue><spage>1026</spage><epage>1030</epage><pages>1026-1030</pages><issn>0340-6245</issn><eissn>2567-689X</eissn><abstract>Summary
Adipose tissue is a secretory organ producing a variety of bioactive substances, such as adiponectin. Adiponectin has antiatherogenic properties while plasminogen activator inhibitor type 1 (PAI-1) is closely involved in the development of atherosclerosis. The relationship between adiponectin and PAI-1 in patients with coronary artery disease (CAD) has not been clarified. This study examined plasma levels of adiponectin and PAI-1 in 64 patients with stable exertional angina (SEA) and 65 patients with the chest pain syndrome (CPS). Plasma logadiponectin levels were significantly lower in patients with SEA (0.62±0.08 µg/dL) compared to those with CPS (0.86± 0.05 µg/dL) (p<0.0001). The plasma levels of log-PAI-1 were significantly higher in patients with SEA (1.23±0.18 ng/mL) compared to those with CPS (1.15±0.22 ng/mL) (p<0.05). Plasma log-adiponectin levels correlated negatively with diabetes mellitus (DM), body mass index (BMI), log-PAI-1 (r=−0.284, p<0.001), triglyceride (TG), and remnant-like particles cholesterol (RLP-C), and positively with high-density lipoprotein cholesterol (HDL-C) levels. Plasma levels of log-PAI-1 correlated positively with DM, BMI, TG and RLP-C levels, and negatively with HDL-C levels. Multiple logistic regression analysis identified sex, angina pectoris, and PAI-1 as independent determinants of hyperadiponectinemia (p<0.05). Adiponectin is inversely related to PAI-1. DM, BMI, TG, HDL-C, and RLP-C are common mediators between adiponectin and PAI-1, and treatment for common mediators may prevent the development of CAD by reducing PAI-1 and increasing adiponectin levels.</abstract><cop>Germany</cop><pub>Schattauer Verlag für Medizin und Naturwissenschaften</pub><pmid>15116265</pmid><doi>10.1160/TH03-12-0731</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-6245 |
| ispartof | Thrombosis and haemostasis, 2004-05, Vol.91 (5), p.1026-1030 |
| issn | 0340-6245 2567-689X |
| language | eng |
| recordid | cdi_pubmed_primary_15116265 |
| source | MEDLINE; Thieme Connect Journals |
| subjects | Adiponectin Adult Aged Aged, 80 and over Angina Pectoris - blood Cell Signaling and Vessel Remodeling Chest Pain - blood Diabetes Mellitus - blood Female Humans Intercellular Signaling Peptides and Proteins - analysis Logistic Models Male Middle Aged Plasminogen Activator Inhibitor 1 - blood Sex Factors |
| title | Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T12%3A15%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adiponectin%20is%20inversely%20related%20to%20plasminogen%20activator%20inhibitor%20type%201%20in%20patients%20with%20stable%20exertional%20angina&rft.jtitle=Thrombosis%20and%20haemostasis&rft.au=Maruyoshi,%20Hidetomo&rft.date=2004-05&rft.volume=91&rft.issue=5&rft.spage=1026&rft.epage=1030&rft.pages=1026-1030&rft.issn=0340-6245&rft.eissn=2567-689X&rft_id=info:doi/10.1160/TH03-12-0731&rft_dat=%3Cproquest_pubme%3E71887673%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71887673&rft_id=info:pmid/15116265&rfr_iscdi=true |