Mechanism of cicaprost-induced desensitization in rat pulmonary artery smooth muscle cells involves a PKA-mediated inhibition of adenylyl cyclase

Division of Respiratory Medicine, Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's and Papworth Hospitals, Cambridge CB2 2QQ, United Kingdom Submitted 4 August 2003 ; accepted in final form 27 March 2004 Long-term infusion of prostacyclin, or its analog...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2004-08, Vol.287 (2), p.L352-L359
Hauptverfasser:	Sobolewski, Anastasia, Jourdan, Karen B, Upton, Paul D, Long, Lu, Morrell, Nicholas W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Animals Antineoplastic Agents - pharmacology Colforsin - analogs & derivatives Colforsin - pharmacology Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Down-Regulation - drug effects Epoprostenol - analogs & derivatives Epoprostenol - pharmacology In Vitro Techniques Isoquinolines - pharmacology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - enzymology Protein Kinase C - metabolism Pulmonary Artery - cytology Rats Sulfonamides Vasodilator Agents - pharmacology
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