Influence of central and peripheral administration of pancreatic polypeptide on gastric mucosa growth
Previous studies have shown that pancreatic polypeptide (PP) inhibits exocrine pancreatic secretion. The aim of present study was to determine the influence of PP administration on gastric growth and blood flow. Study was performed on regularly fed, fasted or fasted and subsequently refed rats. Rats...
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| Veröffentlicht in: | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2004-03, Vol.55 (1 Pt 2), p.223 |
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| container_title | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society |
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| creator | Dembiński, A Warzecha, Z Ceranowicz, P Pawlik, M Dembiński, M Kabat, K Konturek, S J Kownacki, P Hładki, W Pawlik, W W |
| description | Previous studies have shown that pancreatic polypeptide (PP) inhibits exocrine pancreatic secretion. The aim of present study was to determine the influence of PP administration on gastric growth and blood flow.
Study was performed on regularly fed, fasted or fasted and subsequently refed rats. Rats were treated with saline (intraperitoneally - i.p.), caerulein (0.24 nmol/kg/dose, i.p.), pentagastrin (0.38 micromol/kg/dose, i.p.) or PP (5 nmol/kg/dose, i.p. or 10 pmol/dose intracerebroventricularly - i.c.v.). Saline, caerulein, pentagastrin and PP were administered alone or in combination, 3 times daily during last 48 h of experiment.
Treatment with pentagastrin increased gastric mucosa weight, mucosal DNA synthesis and gastric blood flow in all group tested. Intraperitoneal and i.c.v administration of PP alone reduced mucosal DNA synthesis in regularly fed and refed animals, and decreased gastric blood flow in refed animals. Combination of PP i.p. or i.c.v plus pentagastrin significantly reduced the pentagastrin-evoked increase in gastric mucosa weight, gastric DNA synthesis and gastric blood flow in fasted animals, as well as regularly fed animals. In refed animals, influence of PP administration on the pentagastrin-evoked increase in gastric mucosa weight was weak and statistically insignificant, but still i.p or i.c.v administration of PP significantly reduced gastric blood flow and mucosal DNA synthesis in this group of animals. Administration of caerulein caused weak, but significant increase in gastric DNA synthesis, gastric mucosa weight and gastric blood flow in fasted rats. In regularly fed animals, caerulein significantly increased only gastric DNA synthesis and gastric blood flow. In fasted animals with subsequent refeeding, caerulein was without effect on parameters tested in the stomach. Neither i.p. nor i.c.v administration of PP affected the caerulein-evoked effects in the stomach.
Peripheral and central administration of PP inhibits food- and pentagastrin-stimulated growth of gastric mucosa. Similar effects of low central doses of PP as the high peripheral doses of PP suggests a crucial role of the central nervous system in the inhibitory effect of PP on gastric mucosa growth. |
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Study was performed on regularly fed, fasted or fasted and subsequently refed rats. Rats were treated with saline (intraperitoneally - i.p.), caerulein (0.24 nmol/kg/dose, i.p.), pentagastrin (0.38 micromol/kg/dose, i.p.) or PP (5 nmol/kg/dose, i.p. or 10 pmol/dose intracerebroventricularly - i.c.v.). Saline, caerulein, pentagastrin and PP were administered alone or in combination, 3 times daily during last 48 h of experiment.
Treatment with pentagastrin increased gastric mucosa weight, mucosal DNA synthesis and gastric blood flow in all group tested. Intraperitoneal and i.c.v administration of PP alone reduced mucosal DNA synthesis in regularly fed and refed animals, and decreased gastric blood flow in refed animals. Combination of PP i.p. or i.c.v plus pentagastrin significantly reduced the pentagastrin-evoked increase in gastric mucosa weight, gastric DNA synthesis and gastric blood flow in fasted animals, as well as regularly fed animals. In refed animals, influence of PP administration on the pentagastrin-evoked increase in gastric mucosa weight was weak and statistically insignificant, but still i.p or i.c.v administration of PP significantly reduced gastric blood flow and mucosal DNA synthesis in this group of animals. Administration of caerulein caused weak, but significant increase in gastric DNA synthesis, gastric mucosa weight and gastric blood flow in fasted rats. In regularly fed animals, caerulein significantly increased only gastric DNA synthesis and gastric blood flow. In fasted animals with subsequent refeeding, caerulein was without effect on parameters tested in the stomach. Neither i.p. nor i.c.v administration of PP affected the caerulein-evoked effects in the stomach.
Peripheral and central administration of PP inhibits food- and pentagastrin-stimulated growth of gastric mucosa. Similar effects of low central doses of PP as the high peripheral doses of PP suggests a crucial role of the central nervous system in the inhibitory effect of PP on gastric mucosa growth.</description><identifier>ISSN: 0867-5910</identifier><identifier>PMID: 15082880</identifier><language>eng</language><publisher>Poland</publisher><subject>Animals ; Ceruletide - administration & dosage ; Ceruletide - pharmacokinetics ; DNA - biosynthesis ; DNA - drug effects ; Drug Administration Schedule ; Drug Synergism ; Drug Therapy, Combination ; Eating - drug effects ; Eating - physiology ; Food Deprivation - physiology ; Gastric Acid - secretion ; Gastric Mucosa - blood supply ; Gastric Mucosa - drug effects ; Gastric Mucosa - growth & development ; Injections, Intraperitoneal ; Injections, Intraventricular ; Male ; Methods ; Pancreatic Polypeptide - administration & dosage ; Pancreatic Polypeptide - pharmacokinetics ; Parietal Cells, Gastric - drug effects ; Parietal Cells, Gastric - metabolism ; Pentagastrin - administration & dosage ; Pentagastrin - antagonists & inhibitors ; Pentagastrin - pharmacokinetics ; Rats ; Rats, Wistar ; Time Factors</subject><ispartof>Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2004-03, Vol.55 (1 Pt 2), p.223</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15082880$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dembiński, A</creatorcontrib><creatorcontrib>Warzecha, Z</creatorcontrib><creatorcontrib>Ceranowicz, P</creatorcontrib><creatorcontrib>Pawlik, M</creatorcontrib><creatorcontrib>Dembiński, M</creatorcontrib><creatorcontrib>Kabat, K</creatorcontrib><creatorcontrib>Konturek, S J</creatorcontrib><creatorcontrib>Kownacki, P</creatorcontrib><creatorcontrib>Hładki, W</creatorcontrib><creatorcontrib>Pawlik, W W</creatorcontrib><title>Influence of central and peripheral administration of pancreatic polypeptide on gastric mucosa growth</title><title>Journal of physiology and pharmacology : an official journal of the Polish Physiological Society</title><addtitle>J Physiol Pharmacol</addtitle><description>Previous studies have shown that pancreatic polypeptide (PP) inhibits exocrine pancreatic secretion. The aim of present study was to determine the influence of PP administration on gastric growth and blood flow.
Study was performed on regularly fed, fasted or fasted and subsequently refed rats. Rats were treated with saline (intraperitoneally - i.p.), caerulein (0.24 nmol/kg/dose, i.p.), pentagastrin (0.38 micromol/kg/dose, i.p.) or PP (5 nmol/kg/dose, i.p. or 10 pmol/dose intracerebroventricularly - i.c.v.). Saline, caerulein, pentagastrin and PP were administered alone or in combination, 3 times daily during last 48 h of experiment.
Treatment with pentagastrin increased gastric mucosa weight, mucosal DNA synthesis and gastric blood flow in all group tested. Intraperitoneal and i.c.v administration of PP alone reduced mucosal DNA synthesis in regularly fed and refed animals, and decreased gastric blood flow in refed animals. Combination of PP i.p. or i.c.v plus pentagastrin significantly reduced the pentagastrin-evoked increase in gastric mucosa weight, gastric DNA synthesis and gastric blood flow in fasted animals, as well as regularly fed animals. In refed animals, influence of PP administration on the pentagastrin-evoked increase in gastric mucosa weight was weak and statistically insignificant, but still i.p or i.c.v administration of PP significantly reduced gastric blood flow and mucosal DNA synthesis in this group of animals. Administration of caerulein caused weak, but significant increase in gastric DNA synthesis, gastric mucosa weight and gastric blood flow in fasted rats. In regularly fed animals, caerulein significantly increased only gastric DNA synthesis and gastric blood flow. In fasted animals with subsequent refeeding, caerulein was without effect on parameters tested in the stomach. Neither i.p. nor i.c.v administration of PP affected the caerulein-evoked effects in the stomach.
Peripheral and central administration of PP inhibits food- and pentagastrin-stimulated growth of gastric mucosa. Similar effects of low central doses of PP as the high peripheral doses of PP suggests a crucial role of the central nervous system in the inhibitory effect of PP on gastric mucosa growth.</description><subject>Animals</subject><subject>Ceruletide - administration & dosage</subject><subject>Ceruletide - pharmacokinetics</subject><subject>DNA - biosynthesis</subject><subject>DNA - drug effects</subject><subject>Drug Administration Schedule</subject><subject>Drug Synergism</subject><subject>Drug Therapy, Combination</subject><subject>Eating - drug effects</subject><subject>Eating - physiology</subject><subject>Food Deprivation - physiology</subject><subject>Gastric Acid - secretion</subject><subject>Gastric Mucosa - blood supply</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - growth & development</subject><subject>Injections, Intraperitoneal</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Methods</subject><subject>Pancreatic Polypeptide - administration & dosage</subject><subject>Pancreatic Polypeptide - pharmacokinetics</subject><subject>Parietal Cells, Gastric - drug effects</subject><subject>Parietal Cells, Gastric - metabolism</subject><subject>Pentagastrin - administration & dosage</subject><subject>Pentagastrin - antagonists & inhibitors</subject><subject>Pentagastrin - pharmacokinetics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Time Factors</subject><issn>0867-5910</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j8tqwzAURLVoadK0v1D0AwbJ1svLEvoIBLJp10G6ukpUbFnINiV_X_e1Gs7MMDBXZM2M0pVsOVuR23H8YKzmolE3ZMUlM7UxbE1wl0I3YwKkQ6CAaSq2ozZ5mrHEfMYf9H1McVyiKQ7pu5htgoILAs1Dd8mYp-iXiURPduktdj_DMFp6KsPndL4j18F2I97_6Ya8Pz-9bV-r_eFlt33cV7lm7VTZWqMX3Bjt2sCd1EIx1YAXIkjGQQfjuNBOONkKkF6B9zy4mqPiDkCKZkMefnfz7Hr0x1xib8vl-P-3-QLo0VMh</recordid><startdate>200403</startdate><enddate>200403</enddate><creator>Dembiński, A</creator><creator>Warzecha, Z</creator><creator>Ceranowicz, P</creator><creator>Pawlik, M</creator><creator>Dembiński, M</creator><creator>Kabat, K</creator><creator>Konturek, S J</creator><creator>Kownacki, P</creator><creator>Hładki, W</creator><creator>Pawlik, W W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200403</creationdate><title>Influence of central and peripheral administration of pancreatic polypeptide on gastric mucosa growth</title><author>Dembiński, A ; Warzecha, Z ; Ceranowicz, P ; Pawlik, M ; Dembiński, M ; Kabat, K ; Konturek, S J ; Kownacki, P ; Hładki, W ; Pawlik, W W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-a27ed41887b9f1b5746063cd44f501c7f8b147b4b594c5d6cdd1fb21e61bcc543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Ceruletide - administration & dosage</topic><topic>Ceruletide - pharmacokinetics</topic><topic>DNA - biosynthesis</topic><topic>DNA - drug effects</topic><topic>Drug Administration Schedule</topic><topic>Drug Synergism</topic><topic>Drug Therapy, Combination</topic><topic>Eating - drug effects</topic><topic>Eating - physiology</topic><topic>Food Deprivation - physiology</topic><topic>Gastric Acid - secretion</topic><topic>Gastric Mucosa - blood supply</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - growth & development</topic><topic>Injections, Intraperitoneal</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Methods</topic><topic>Pancreatic Polypeptide - administration & dosage</topic><topic>Pancreatic Polypeptide - pharmacokinetics</topic><topic>Parietal Cells, Gastric - drug effects</topic><topic>Parietal Cells, Gastric - metabolism</topic><topic>Pentagastrin - administration & dosage</topic><topic>Pentagastrin - antagonists & inhibitors</topic><topic>Pentagastrin - pharmacokinetics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dembiński, A</creatorcontrib><creatorcontrib>Warzecha, Z</creatorcontrib><creatorcontrib>Ceranowicz, P</creatorcontrib><creatorcontrib>Pawlik, M</creatorcontrib><creatorcontrib>Dembiński, M</creatorcontrib><creatorcontrib>Kabat, K</creatorcontrib><creatorcontrib>Konturek, S J</creatorcontrib><creatorcontrib>Kownacki, P</creatorcontrib><creatorcontrib>Hładki, W</creatorcontrib><creatorcontrib>Pawlik, W W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of physiology and pharmacology : an official journal of the Polish Physiological Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dembiński, A</au><au>Warzecha, Z</au><au>Ceranowicz, P</au><au>Pawlik, M</au><au>Dembiński, M</au><au>Kabat, K</au><au>Konturek, S J</au><au>Kownacki, P</au><au>Hładki, W</au><au>Pawlik, W W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of central and peripheral administration of pancreatic polypeptide on gastric mucosa growth</atitle><jtitle>Journal of physiology and pharmacology : an official journal of the Polish Physiological Society</jtitle><addtitle>J Physiol Pharmacol</addtitle><date>2004-03</date><risdate>2004</risdate><volume>55</volume><issue>1 Pt 2</issue><spage>223</spage><pages>223-</pages><issn>0867-5910</issn><abstract>Previous studies have shown that pancreatic polypeptide (PP) inhibits exocrine pancreatic secretion. The aim of present study was to determine the influence of PP administration on gastric growth and blood flow.
Study was performed on regularly fed, fasted or fasted and subsequently refed rats. Rats were treated with saline (intraperitoneally - i.p.), caerulein (0.24 nmol/kg/dose, i.p.), pentagastrin (0.38 micromol/kg/dose, i.p.) or PP (5 nmol/kg/dose, i.p. or 10 pmol/dose intracerebroventricularly - i.c.v.). Saline, caerulein, pentagastrin and PP were administered alone or in combination, 3 times daily during last 48 h of experiment.
Treatment with pentagastrin increased gastric mucosa weight, mucosal DNA synthesis and gastric blood flow in all group tested. Intraperitoneal and i.c.v administration of PP alone reduced mucosal DNA synthesis in regularly fed and refed animals, and decreased gastric blood flow in refed animals. Combination of PP i.p. or i.c.v plus pentagastrin significantly reduced the pentagastrin-evoked increase in gastric mucosa weight, gastric DNA synthesis and gastric blood flow in fasted animals, as well as regularly fed animals. In refed animals, influence of PP administration on the pentagastrin-evoked increase in gastric mucosa weight was weak and statistically insignificant, but still i.p or i.c.v administration of PP significantly reduced gastric blood flow and mucosal DNA synthesis in this group of animals. Administration of caerulein caused weak, but significant increase in gastric DNA synthesis, gastric mucosa weight and gastric blood flow in fasted rats. In regularly fed animals, caerulein significantly increased only gastric DNA synthesis and gastric blood flow. In fasted animals with subsequent refeeding, caerulein was without effect on parameters tested in the stomach. Neither i.p. nor i.c.v administration of PP affected the caerulein-evoked effects in the stomach.
Peripheral and central administration of PP inhibits food- and pentagastrin-stimulated growth of gastric mucosa. Similar effects of low central doses of PP as the high peripheral doses of PP suggests a crucial role of the central nervous system in the inhibitory effect of PP on gastric mucosa growth.</abstract><cop>Poland</cop><pmid>15082880</pmid></addata></record> |
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| subjects | Animals Ceruletide - administration & dosage Ceruletide - pharmacokinetics DNA - biosynthesis DNA - drug effects Drug Administration Schedule Drug Synergism Drug Therapy, Combination Eating - drug effects Eating - physiology Food Deprivation - physiology Gastric Acid - secretion Gastric Mucosa - blood supply Gastric Mucosa - drug effects Gastric Mucosa - growth & development Injections, Intraperitoneal Injections, Intraventricular Male Methods Pancreatic Polypeptide - administration & dosage Pancreatic Polypeptide - pharmacokinetics Parietal Cells, Gastric - drug effects Parietal Cells, Gastric - metabolism Pentagastrin - administration & dosage Pentagastrin - antagonists & inhibitors Pentagastrin - pharmacokinetics Rats Rats, Wistar Time Factors |
| title | Influence of central and peripheral administration of pancreatic polypeptide on gastric mucosa growth |
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