Synthesis, Biological Activity and Molecular Modeling of 6-Benzylthioinosine Analogues as Subversive Substrates of Toxoplasma gondii Adenosine Kinase

Toxoplasma gondii is the most common cause of secondary CNS infections in immunocompromised persons such as AIDS patients. The major route of adenosine metabolism in T. gondii is direct phosphorylation to adenosine 5'-monophosphate (AMP) catalyzed by the enzyme adenosine kinase (EC 2.7.1.20). A...

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Veröffentlicht in:	Journal of medicinal chemistry 2004-04, Vol.47 (8), p.1987-1996
Hauptverfasser:	YADAV, Vikas, CHU, Chung K., RAIS, Reem H., AL SAFARJALANI, Omar N., GUARCELLO, Vincenzo, NAGUIB, Fardos N. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Kinase - chemistry Adenosine Kinase - deficiency Adenosine Kinase - metabolism Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Cells, Cultured Coccidiostats - chemical synthesis Coccidiostats - chemistry Coccidiostats - pharmacology Combinatorial Chemistry Techniques Humans Medical sciences Models, Molecular Pharmacology. Drug treatments Structure-Activity Relationship Thioinosine - analogs & derivatives Thioinosine - chemical synthesis Thioinosine - chemistry Thioinosine - pharmacology Toxoplasma - drug effects Toxoplasma - enzymology
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