The evaluation of the genotoxicity of two commonly used food colors: Quinoline Yellow (E 104) and Brilliant Black BN (E 151)
Additives, especially colors, are in widespread use in the food industry. With the exception of the quinolines, food colors are relatively weak mutagens and are certified as safe additives despite reports that some people have allergic reactions to them. The number of food additives is still on the...
Gespeichert in:
| Veröffentlicht in: | Cellular & molecular biology letters 2004, Vol.9 (1), p.107 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 107 |
| container_title | Cellular & molecular biology letters |
| container_volume | 9 |
| creator | Macioszek, Violetta K Kononowicz, Andrzej K |
| description | Additives, especially colors, are in widespread use in the food industry. With the exception of the quinolines, food colors are relatively weak mutagens and are certified as safe additives despite reports that some people have allergic reactions to them. The number of food additives is still on the increase, and research on their potential mutagenic/carcinogenic activity in vivo is very expensive. Using two different cellular model systems, human lymphocytes in vitro and Vicia faba root tip meristems of in vivo, we evaluated the potential cytological and genotoxic effects of two dyes: Quinoline Yellow (E 104) and Brilliant Black BN (E 151). Two relatively new, very sensitive and rapid tests - the micronucleus and Comet assays - were used in this study. The data provided in this paper showed the genotoxic effects of the two analyzed food colors, and confirmed the diagnostic value of the MN and Comet assays for screening potentially genotoxic substances. |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_15048155</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15048155</sourcerecordid><originalsourceid>FETCH-LOGICAL-p207t-e4fdf2a975daadd9edd930362385aa0e6c6b2c1a47ee3468c3bd136778079ce83</originalsourceid><addsrcrecordid>eNo10EtLAzEUBeAsFFurf0Hu0i4GkkkyM3VnS31AUYS6cFVukzsazSRlHtYBf7xD1cXlwHfgLO4RGwuV6qQQWo7YadO8c55ypfgJGwnN1eB6zL7XbwT0ib7D1sUAsYR2kFcKsY1fzri2P9g-golVFYPvoWvIQhmjHcjHurmCp86F6F0geCHv4x4ulyC4mgIGC_Paee8wtDD3aD5g_nCotZieseMSfUPnfzlhzzfL9eIuWT3e3i-uV8ku5XmbkCptmeIs1xbR2hkNJ7nMUlloRE6ZybapEahyIqmywsitFTLL84LnM0OFnLCL391dt63Ibna1q7DuN_9vkD9aVFeK</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The evaluation of the genotoxicity of two commonly used food colors: Quinoline Yellow (E 104) and Brilliant Black BN (E 151)</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Macioszek, Violetta K ; Kononowicz, Andrzej K</creator><creatorcontrib>Macioszek, Violetta K ; Kononowicz, Andrzej K</creatorcontrib><description>Additives, especially colors, are in widespread use in the food industry. With the exception of the quinolines, food colors are relatively weak mutagens and are certified as safe additives despite reports that some people have allergic reactions to them. The number of food additives is still on the increase, and research on their potential mutagenic/carcinogenic activity in vivo is very expensive. Using two different cellular model systems, human lymphocytes in vitro and Vicia faba root tip meristems of in vivo, we evaluated the potential cytological and genotoxic effects of two dyes: Quinoline Yellow (E 104) and Brilliant Black BN (E 151). Two relatively new, very sensitive and rapid tests - the micronucleus and Comet assays - were used in this study. The data provided in this paper showed the genotoxic effects of the two analyzed food colors, and confirmed the diagnostic value of the MN and Comet assays for screening potentially genotoxic substances.</description><identifier>ISSN: 1425-8153</identifier><identifier>PMID: 15048155</identifier><language>eng</language><publisher>England</publisher><subject>Azo Compounds - toxicity ; Comet Assay ; DNA Fragmentation - drug effects ; Food Coloring Agents - toxicity ; Humans ; Lymphocytes - cytology ; Lymphocytes - drug effects ; Meristem - cytology ; Meristem - genetics ; Mutagenicity Tests ; Plant Root Cap - cytology ; Plant Root Cap - drug effects ; Quinolines - toxicity ; Vicia faba - cytology ; Vicia faba - drug effects ; Vicia faba - genetics</subject><ispartof>Cellular & molecular biology letters, 2004, Vol.9 (1), p.107</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15048155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Macioszek, Violetta K</creatorcontrib><creatorcontrib>Kononowicz, Andrzej K</creatorcontrib><title>The evaluation of the genotoxicity of two commonly used food colors: Quinoline Yellow (E 104) and Brilliant Black BN (E 151)</title><title>Cellular & molecular biology letters</title><addtitle>Cell Mol Biol Lett</addtitle><description>Additives, especially colors, are in widespread use in the food industry. With the exception of the quinolines, food colors are relatively weak mutagens and are certified as safe additives despite reports that some people have allergic reactions to them. The number of food additives is still on the increase, and research on their potential mutagenic/carcinogenic activity in vivo is very expensive. Using two different cellular model systems, human lymphocytes in vitro and Vicia faba root tip meristems of in vivo, we evaluated the potential cytological and genotoxic effects of two dyes: Quinoline Yellow (E 104) and Brilliant Black BN (E 151). Two relatively new, very sensitive and rapid tests - the micronucleus and Comet assays - were used in this study. The data provided in this paper showed the genotoxic effects of the two analyzed food colors, and confirmed the diagnostic value of the MN and Comet assays for screening potentially genotoxic substances.</description><subject>Azo Compounds - toxicity</subject><subject>Comet Assay</subject><subject>DNA Fragmentation - drug effects</subject><subject>Food Coloring Agents - toxicity</subject><subject>Humans</subject><subject>Lymphocytes - cytology</subject><subject>Lymphocytes - drug effects</subject><subject>Meristem - cytology</subject><subject>Meristem - genetics</subject><subject>Mutagenicity Tests</subject><subject>Plant Root Cap - cytology</subject><subject>Plant Root Cap - drug effects</subject><subject>Quinolines - toxicity</subject><subject>Vicia faba - cytology</subject><subject>Vicia faba - drug effects</subject><subject>Vicia faba - genetics</subject><issn>1425-8153</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10EtLAzEUBeAsFFurf0Hu0i4GkkkyM3VnS31AUYS6cFVukzsazSRlHtYBf7xD1cXlwHfgLO4RGwuV6qQQWo7YadO8c55ypfgJGwnN1eB6zL7XbwT0ib7D1sUAsYR2kFcKsY1fzri2P9g-golVFYPvoWvIQhmjHcjHurmCp86F6F0geCHv4x4ulyC4mgIGC_Paee8wtDD3aD5g_nCotZieseMSfUPnfzlhzzfL9eIuWT3e3i-uV8ku5XmbkCptmeIs1xbR2hkNJ7nMUlloRE6ZybapEahyIqmywsitFTLL84LnM0OFnLCL391dt63Ibna1q7DuN_9vkD9aVFeK</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Macioszek, Violetta K</creator><creator>Kononowicz, Andrzej K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>2004</creationdate><title>The evaluation of the genotoxicity of two commonly used food colors: Quinoline Yellow (E 104) and Brilliant Black BN (E 151)</title><author>Macioszek, Violetta K ; Kononowicz, Andrzej K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p207t-e4fdf2a975daadd9edd930362385aa0e6c6b2c1a47ee3468c3bd136778079ce83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Azo Compounds - toxicity</topic><topic>Comet Assay</topic><topic>DNA Fragmentation - drug effects</topic><topic>Food Coloring Agents - toxicity</topic><topic>Humans</topic><topic>Lymphocytes - cytology</topic><topic>Lymphocytes - drug effects</topic><topic>Meristem - cytology</topic><topic>Meristem - genetics</topic><topic>Mutagenicity Tests</topic><topic>Plant Root Cap - cytology</topic><topic>Plant Root Cap - drug effects</topic><topic>Quinolines - toxicity</topic><topic>Vicia faba - cytology</topic><topic>Vicia faba - drug effects</topic><topic>Vicia faba - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Macioszek, Violetta K</creatorcontrib><creatorcontrib>Kononowicz, Andrzej K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cellular & molecular biology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Macioszek, Violetta K</au><au>Kononowicz, Andrzej K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The evaluation of the genotoxicity of two commonly used food colors: Quinoline Yellow (E 104) and Brilliant Black BN (E 151)</atitle><jtitle>Cellular & molecular biology letters</jtitle><addtitle>Cell Mol Biol Lett</addtitle><date>2004</date><risdate>2004</risdate><volume>9</volume><issue>1</issue><spage>107</spage><pages>107-</pages><issn>1425-8153</issn><abstract>Additives, especially colors, are in widespread use in the food industry. With the exception of the quinolines, food colors are relatively weak mutagens and are certified as safe additives despite reports that some people have allergic reactions to them. The number of food additives is still on the increase, and research on their potential mutagenic/carcinogenic activity in vivo is very expensive. Using two different cellular model systems, human lymphocytes in vitro and Vicia faba root tip meristems of in vivo, we evaluated the potential cytological and genotoxic effects of two dyes: Quinoline Yellow (E 104) and Brilliant Black BN (E 151). Two relatively new, very sensitive and rapid tests - the micronucleus and Comet assays - were used in this study. The data provided in this paper showed the genotoxic effects of the two analyzed food colors, and confirmed the diagnostic value of the MN and Comet assays for screening potentially genotoxic substances.</abstract><cop>England</cop><pmid>15048155</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1425-8153 |
| ispartof | Cellular & molecular biology letters, 2004, Vol.9 (1), p.107 |
| issn | 1425-8153 |
| language | eng |
| recordid | cdi_pubmed_primary_15048155 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Azo Compounds - toxicity Comet Assay DNA Fragmentation - drug effects Food Coloring Agents - toxicity Humans Lymphocytes - cytology Lymphocytes - drug effects Meristem - cytology Meristem - genetics Mutagenicity Tests Plant Root Cap - cytology Plant Root Cap - drug effects Quinolines - toxicity Vicia faba - cytology Vicia faba - drug effects Vicia faba - genetics |
| title | The evaluation of the genotoxicity of two commonly used food colors: Quinoline Yellow (E 104) and Brilliant Black BN (E 151) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T04%3A44%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20evaluation%20of%20the%20genotoxicity%20of%20two%20commonly%20used%20food%20colors:%20Quinoline%20Yellow%20(E%20104)%20and%20Brilliant%20Black%20BN%20(E%20151)&rft.jtitle=Cellular%20&%20molecular%20biology%20letters&rft.au=Macioszek,%20Violetta%20K&rft.date=2004&rft.volume=9&rft.issue=1&rft.spage=107&rft.pages=107-&rft.issn=1425-8153&rft_id=info:doi/&rft_dat=%3Cpubmed%3E15048155%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/15048155&rfr_iscdi=true |