Small-molecule antagonists of p53-MDM2 binding: research tools and potential therapeutics

p53 regulates a key pathway which protects normal tissues from tumor development that may result from diverse forms of stress. In the absence of stress, growth suppressive and proapoptotic activity of p53 is inhibited by MDM2 which binds p53 and negatively regulates its activity and stability. MDM2...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2004-04, Vol.3 (4), p.419
1. Verfasser:	Vassilev, Lyubomir T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis Cell Division Cell Line, Tumor Cell Survival Culture Media Dose-Response Relationship, Drug Fibroblasts - metabolism Gene Expression Regulation, Neoplastic Humans Imidazoles - metabolism Inhibitory Concentration 50 Mice Mice, Nude Neoplasm Transplantation Neoplasms - metabolism NIH 3T3 Cells Nuclear Proteins - metabolism Osteosarcoma - metabolism Piperazines - metabolism Protein Binding Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-mdm2 Tumor Suppressor Protein p53 - metabolism
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