Propranolol and verapamil inhibit mRNA expression of RyR2 and SERCA in L-thyroxin-induced rat ventricular hypertrophy

AIM: To study the alteration in the mRNA level of cardiac ryanodine receptor 2 (RyR2) and sarco-endoplasmic reticulum Ca^2+-ATPase (SERCA) in L-thyroxin-induced hypertrophy. METHODS: L-thyroxin (500 g/kg) daily was injected for 10 d. RT-PCR was used to determine mRNA expression. RESULTS: An increase...

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Veröffentlicht in:	Acta pharmacologica Sinica 2004-03, Vol.25 (3), p.347-351
Hauptverfasser:	Wu, Xiao-dong, Dai, De-zai, Zhang, Qiu-pin, Gao, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Animals Anti-Arrhythmia Agents - pharmacology Calcium Channel Blockers - pharmacology Calcium-Transporting ATPases - biosynthesis Calcium-Transporting ATPases - genetics Cardiomegaly - chemically induced Cardiomegaly - genetics Cardiomegaly - metabolism Female L-甲状腺素 Male mRNA Myocardium - metabolism Propranolol - pharmacology Random Allocation Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Ryanodine Receptor Calcium Release Channel - biosynthesis Ryanodine Receptor Calcium Release Channel - genetics RyR2 Sarcoplasmic Reticulum Calcium-Transporting ATPases SERCA Thyroxine Verapamil - pharmacology 分子机制异博定心室肥大心得安
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