Toll-Like Receptors 9 and 3 As Essential Components of Innate Immune Defense against Mouse Cytomegalovirus Infection

Several subsets of dendritic cells have been shown to produce type I IFN in response to viral infections, thereby assisting the natural killer cell-dependent response that eliminates the pathogen. Type I IFN production can be induced both by unmethylated CpG-oligode-oxynucleotide and by double-stran...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-03, Vol.101 (10), p.3516-3521
Hauptverfasser:	Tabeta, Koichi, Georgel, Philippe, Janssen, Edith, Du, Xin, Hoebe, Kasper, Crozat, Karine, Mudd, Suzanne, Shamel, Louis, Sovath, Sosathya, Goode, Jason, Alexopoulou, Lena, Flavell, Richard A., Beutler, Bruce
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Alleles Amino Acid Sequence Amino acids Animals Antigens, Differentiation - genetics Antigens, Differentiation - metabolism Biological Sciences Cells Cytokines Cytokines - biosynthesis Cytomegalovirus Infections - genetics Cytomegalovirus Infections - immunology DNA, Complementary - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Double stranded RNA Genes Genotype & phenotype Genotypes Immunity, Innate - drug effects Immunity, Innate - genetics Immunology Infections Killer Cells, Natural - immunology Life Sciences Membrane Glycoproteins - deficiency Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Molecular Sequence Data Murine cytomegalovirus Mutation Mutation, Missense Myeloid Differentiation Factor 88 Natural killer T cells Oligodeoxyribonucleotides - genetics Oligodeoxyribonucleotides - pharmacology Pathogens Phenotype Phenotypes Point Mutation Receptors Receptors, Cell Surface - deficiency Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Immunologic - deficiency Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Ribonucleic acid RNA Sequence Homology, Amino Acid Signal Transduction T cell receptors Toll-Like Receptor 3 Toll-Like Receptor 9 Toll-Like Receptors Viral infections Viruses
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