Suppression of cytokines and nitric oxide production, and protection against lethal endotoxemia and viral myocarditis by a new NF-kappaB inhibitor

Nuclear factor kappa B (NF-kappaB) is activated by several factors, which increase the inflammatory response, and this activation, in turn, leads to the expression of several genes such as cytokines, and may play an important role in cardiovascular diseases. The aim of the study is to examine the ef...

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Veröffentlicht in:	European journal of heart failure 2004-03, Vol.6 (2), p.137
Hauptverfasser:	Matsumori, Akira, Nunokawa, Youichi, Yamaki, Akira, Yamamoto, Kanjo, Hwang, Myung-Woo, Miyamoto, Tadashi, Hara, Masatake, Nishio, Ryosuke, Kitaura-Inenaga, Katsura, Ono, Koh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiovirus Infections - drug therapy Cardiovirus Infections - prevention & control Cardiovirus Infections - virology Cell Nucleus - metabolism Cells, Cultured DNA, Complementary - metabolism Encephalomyocarditis virus Endotoxemia - drug therapy Endotoxemia - etiology Endotoxemia - prevention & control Female Gene Expression Regulation - drug effects Humans In Vitro Techniques Interleukin-1 - biosynthesis Interleukin-1 - genetics Lipopolysaccharides - toxicity Male Mice Mice, Inbred BALB C Mice, Inbred DBA Myocarditis - drug therapy Myocarditis - prevention & control Myocarditis - virology NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Piperidines - pharmacology Piperidines - therapeutic use Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Tumor Cells, Cultured Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics
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