Radiation-Induced Atherosclerotic Plaque Progression in a Hypercholesterolemic Rabbit: A Prospective Vulnerable Plaque Model?

Human observations provide rich soil for making hypotheses, but good animal models are essential for understanding the disease and to test treatment modalities. Currently, there is no standard animal model of vulnerable plaque; therefore, the purpose of this study is to develop a pathophysiologicall...

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Veröffentlicht in:	Cardiovascular radiation medicine 2003-07, Vol.4 (3), p.146-151
Hauptverfasser:	Pakala, Rajbabu, Leborgne, Laurent, Cheneau, Edouard, Chan, Rosanna C., Yazdi, Hamid, Fournadjiev, Jana, Weber, Deena, Hellinga, David, Kolodgie, Frank, Virmani, Renu, Waksman, Ron
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteries - metabolism Arteries - pathology Arteries - radiation effects Arteriosclerosis - etiology Arteriosclerosis - metabolism Arteriosclerosis - pathology Atherosclerosis Disease Models, Animal Disease Progression Hypercholesterolemia - metabolism Hypercholesterolemia - pathology Immunohistochemistry Lipids - blood Macrophages Macrophages - metabolism Macrophages - pathology Macrophages - radiation effects Male Matrix Metalloproteinase 1 - metabolism Metalloproteinases Models, Cardiovascular Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Myocytes, Smooth Muscle - radiation effects Prospective Studies Rabbits Radiation Radiation Injuries, Experimental - etiology Radiation Injuries, Experimental - metabolism Radiation Injuries, Experimental - pathology Smooth muscle cells Tunica Intima - metabolism Tunica Intima - pathology Tunica Intima - radiation effects Vulnerable plaque
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