Cytotoxicity and oxidative stress induced by the glyceraldehyde-related maillard reaction products for HL-60 cells
We demonstrated the cytotoxicity of glyceraldehyde-related Maillard reaction products for HL-60 cells. Glyceraldehyde-modified bovine serum albumin and glyceraldehyde-modified casein inhibited the proliferation of HL-60 cells. The reaction products formed from glyceraldehyde and N α -acetyllysine ha...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2004-02, Vol.68 (2), p.333-340 |
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| creator | Usui, T. (Meiji Univ., Kawasaki, Kanagawa (Japan). Faculty of Agriculture) Shizuuchi, S Watanabe, H Hayase, F |
| description | We demonstrated the cytotoxicity of glyceraldehyde-related Maillard reaction products for HL-60 cells. Glyceraldehyde-modified bovine serum albumin and glyceraldehyde-modified casein inhibited the proliferation of HL-60 cells. The reaction products formed from glyceraldehyde and N
α
-acetyllysine had also a cytotoxic effect on HL-60 cells. The cytotoxic effect was prevented by N-acetylcysteine or pyrrolidinedithiocarbamate as the antioxidants. In addition, the reaction products depressed the intracellular glutathione level, and induced the reactive oxygen species (ROS) production. These results suggested that the glyceraldehyde-related advanced glycation end products (AGEs) induced the cytotoxicity and the oxidative stress.
We previously reported that the glyceraldehyde-related AGE was identified as 1-(5-acetylamino-5-carboxypentyl)-3-hydroxy-5-hydroxymethyl-pyridinium, named GLAP (glyceraldehyde-derived pyridinium compound), formed from glyceraldehyde and N
α
-acetyllysine (Biosci. Biotechnol. Biochem., 67, 930-932 (2003)). In this study, GLAP inhibited the proliferation of HL-60 cells, and the inhibitory effect was prevented by the antioxidants. Furthermore, GLAP depressed the intracellular glutathione level, and induced the ROS production.
This work indicated the possibility that the cytotoxicity and the oxidative stress in the progression of diabetic complications and chronic renal disease might be induced by GLAP. |
| doi_str_mv | 10.1271/bbb.68.333 |
| format | Article |
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α
-acetyllysine had also a cytotoxic effect on HL-60 cells. The cytotoxic effect was prevented by N-acetylcysteine or pyrrolidinedithiocarbamate as the antioxidants. In addition, the reaction products depressed the intracellular glutathione level, and induced the reactive oxygen species (ROS) production. These results suggested that the glyceraldehyde-related advanced glycation end products (AGEs) induced the cytotoxicity and the oxidative stress.
We previously reported that the glyceraldehyde-related AGE was identified as 1-(5-acetylamino-5-carboxypentyl)-3-hydroxy-5-hydroxymethyl-pyridinium, named GLAP (glyceraldehyde-derived pyridinium compound), formed from glyceraldehyde and N
α
-acetyllysine (Biosci. Biotechnol. Biochem., 67, 930-932 (2003)). In this study, GLAP inhibited the proliferation of HL-60 cells, and the inhibitory effect was prevented by the antioxidants. Furthermore, GLAP depressed the intracellular glutathione level, and induced the ROS production.
This work indicated the possibility that the cytotoxicity and the oxidative stress in the progression of diabetic complications and chronic renal disease might be induced by GLAP.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.68.333</identifier><identifier>PMID: 14981296</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>advanced glycation end products ; ALDEHYDES ; Antioxidants - pharmacology ; Biological and medical sciences ; Cell Survival - drug effects ; Chromatography, High Pressure Liquid ; cytotoxicity ; Fundamental and applied biological sciences. Psychology ; Glutathione - metabolism ; glyceraldehyde ; Glyceraldehyde - chemistry ; Glyceraldehyde - isolation & purification ; Glyceraldehyde - toxicity ; HL-60 Cells ; Humans ; Immunohistochemistry ; Lysine - analogs & derivatives ; Lysine - chemistry ; MAILLARD REACTION ; oxidative stress ; Oxidative Stress - drug effects ; Pyridinium Compounds - chemistry ; Pyridinium Compounds - isolation & purification ; Pyridinium Compounds - toxicity ; Reactive Oxygen Species - metabolism ; Serum Albumin, Bovine - chemistry ; STRESS ; TOXICITY</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2004-02, Vol.68 (2), p.333-340</ispartof><rights>2004 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2004</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c637t-10890ccaaf303db5e1bf6b63fc8db272110a8c6c97a33af0f273ec24d23c37c83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15788635$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14981296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Usui, T. (Meiji Univ., Kawasaki, Kanagawa (Japan). Faculty of Agriculture)</creatorcontrib><creatorcontrib>Shizuuchi, S</creatorcontrib><creatorcontrib>Watanabe, H</creatorcontrib><creatorcontrib>Hayase, F</creatorcontrib><title>Cytotoxicity and oxidative stress induced by the glyceraldehyde-related maillard reaction products for HL-60 cells</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>We demonstrated the cytotoxicity of glyceraldehyde-related Maillard reaction products for HL-60 cells. Glyceraldehyde-modified bovine serum albumin and glyceraldehyde-modified casein inhibited the proliferation of HL-60 cells. The reaction products formed from glyceraldehyde and N
α
-acetyllysine had also a cytotoxic effect on HL-60 cells. The cytotoxic effect was prevented by N-acetylcysteine or pyrrolidinedithiocarbamate as the antioxidants. In addition, the reaction products depressed the intracellular glutathione level, and induced the reactive oxygen species (ROS) production. These results suggested that the glyceraldehyde-related advanced glycation end products (AGEs) induced the cytotoxicity and the oxidative stress.
We previously reported that the glyceraldehyde-related AGE was identified as 1-(5-acetylamino-5-carboxypentyl)-3-hydroxy-5-hydroxymethyl-pyridinium, named GLAP (glyceraldehyde-derived pyridinium compound), formed from glyceraldehyde and N
α
-acetyllysine (Biosci. Biotechnol. Biochem., 67, 930-932 (2003)). In this study, GLAP inhibited the proliferation of HL-60 cells, and the inhibitory effect was prevented by the antioxidants. Furthermore, GLAP depressed the intracellular glutathione level, and induced the ROS production.
This work indicated the possibility that the cytotoxicity and the oxidative stress in the progression of diabetic complications and chronic renal disease might be induced by GLAP.</description><subject>advanced glycation end products</subject><subject>ALDEHYDES</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Survival - drug effects</subject><subject>Chromatography, High Pressure Liquid</subject><subject>cytotoxicity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutathione - metabolism</subject><subject>glyceraldehyde</subject><subject>Glyceraldehyde - chemistry</subject><subject>Glyceraldehyde - isolation & purification</subject><subject>Glyceraldehyde - toxicity</subject><subject>HL-60 Cells</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lysine - analogs & derivatives</subject><subject>Lysine - chemistry</subject><subject>MAILLARD REACTION</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pyridinium Compounds - chemistry</subject><subject>Pyridinium Compounds - isolation & purification</subject><subject>Pyridinium Compounds - toxicity</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Serum Albumin, Bovine - chemistry</subject><subject>STRESS</subject><subject>TOXICITY</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc9vFCEUx0lTY9fqpXcNifHSZFYYZoA5mo1azSZ60DN5_Gpp2KEFtjr_vZjdppeeeIHP9_HyeQhdULKmvaAftdZrLteMsRO0omwQHZ8GcYpWZKK8k8NIz9CrUm4JaRcjfYnO6DBJ2k98hfJmqammv8GEumCYLW61hRoeHC41u1JwmO3eOIv1guuNw9dxMS5DtO5msa7LLkJtrzsIMUK2ODswNaQZ3-XUgrVgnzK-2nacYONiLK_RCw-xuDfH8xz9_vL51-aq2_74-m3zadsZzkTtKJETMQbAM8KsHh3VnmvOvJFW96KnlIA03EwCGANPfC-YM_1ge2aYMJKdo_eHvm2Q-70rVd2mfZ7bl4oOTQARhItGXR4ok1Mp2Xl1l8MO8qIoUf_1qqZXcama3ga_O7bc652zT-jRZwM-HAEoBqLPMJtQnrhRSMnZ2LjxwIW52dnBn5SjVRWWmPJjiD07wNtDzkNScJ0b9v1nT8jYdstHzv4Bt1Oe-Q</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Usui, T. (Meiji Univ., Kawasaki, Kanagawa (Japan). Faculty of Agriculture)</creator><creator>Shizuuchi, S</creator><creator>Watanabe, H</creator><creator>Hayase, F</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20040201</creationdate><title>Cytotoxicity and oxidative stress induced by the glyceraldehyde-related maillard reaction products for HL-60 cells</title><author>Usui, T. (Meiji Univ., Kawasaki, Kanagawa (Japan). Faculty of Agriculture) ; Shizuuchi, S ; Watanabe, H ; Hayase, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c637t-10890ccaaf303db5e1bf6b63fc8db272110a8c6c97a33af0f273ec24d23c37c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>advanced glycation end products</topic><topic>ALDEHYDES</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Survival - drug effects</topic><topic>Chromatography, High Pressure Liquid</topic><topic>cytotoxicity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutathione - metabolism</topic><topic>glyceraldehyde</topic><topic>Glyceraldehyde - chemistry</topic><topic>Glyceraldehyde - isolation & purification</topic><topic>Glyceraldehyde - toxicity</topic><topic>HL-60 Cells</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lysine - analogs & derivatives</topic><topic>Lysine - chemistry</topic><topic>MAILLARD REACTION</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Pyridinium Compounds - chemistry</topic><topic>Pyridinium Compounds - isolation & purification</topic><topic>Pyridinium Compounds - toxicity</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Serum Albumin, Bovine - chemistry</topic><topic>STRESS</topic><topic>TOXICITY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Usui, T. (Meiji Univ., Kawasaki, Kanagawa (Japan). Faculty of Agriculture)</creatorcontrib><creatorcontrib>Shizuuchi, S</creatorcontrib><creatorcontrib>Watanabe, H</creatorcontrib><creatorcontrib>Hayase, F</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Usui, T. (Meiji Univ., Kawasaki, Kanagawa (Japan). Faculty of Agriculture)</au><au>Shizuuchi, S</au><au>Watanabe, H</au><au>Hayase, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxicity and oxidative stress induced by the glyceraldehyde-related maillard reaction products for HL-60 cells</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>68</volume><issue>2</issue><spage>333</spage><epage>340</epage><pages>333-340</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>We demonstrated the cytotoxicity of glyceraldehyde-related Maillard reaction products for HL-60 cells. Glyceraldehyde-modified bovine serum albumin and glyceraldehyde-modified casein inhibited the proliferation of HL-60 cells. The reaction products formed from glyceraldehyde and N
α
-acetyllysine had also a cytotoxic effect on HL-60 cells. The cytotoxic effect was prevented by N-acetylcysteine or pyrrolidinedithiocarbamate as the antioxidants. In addition, the reaction products depressed the intracellular glutathione level, and induced the reactive oxygen species (ROS) production. These results suggested that the glyceraldehyde-related advanced glycation end products (AGEs) induced the cytotoxicity and the oxidative stress.
We previously reported that the glyceraldehyde-related AGE was identified as 1-(5-acetylamino-5-carboxypentyl)-3-hydroxy-5-hydroxymethyl-pyridinium, named GLAP (glyceraldehyde-derived pyridinium compound), formed from glyceraldehyde and N
α
-acetyllysine (Biosci. Biotechnol. Biochem., 67, 930-932 (2003)). In this study, GLAP inhibited the proliferation of HL-60 cells, and the inhibitory effect was prevented by the antioxidants. Furthermore, GLAP depressed the intracellular glutathione level, and induced the ROS production.
This work indicated the possibility that the cytotoxicity and the oxidative stress in the progression of diabetic complications and chronic renal disease might be induced by GLAP.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>14981296</pmid><doi>10.1271/bbb.68.333</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Freely Accessible Japanese Titles; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | advanced glycation end products ALDEHYDES Antioxidants - pharmacology Biological and medical sciences Cell Survival - drug effects Chromatography, High Pressure Liquid cytotoxicity Fundamental and applied biological sciences. Psychology Glutathione - metabolism glyceraldehyde Glyceraldehyde - chemistry Glyceraldehyde - isolation & purification Glyceraldehyde - toxicity HL-60 Cells Humans Immunohistochemistry Lysine - analogs & derivatives Lysine - chemistry MAILLARD REACTION oxidative stress Oxidative Stress - drug effects Pyridinium Compounds - chemistry Pyridinium Compounds - isolation & purification Pyridinium Compounds - toxicity Reactive Oxygen Species - metabolism Serum Albumin, Bovine - chemistry STRESS TOXICITY |
| title | Cytotoxicity and oxidative stress induced by the glyceraldehyde-related maillard reaction products for HL-60 cells |
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