Evaluation of the cumulative (repeated application) eye irritation and corneal staining potential of FD&C yellow No. 5, FD&C blue No. 1 and FD&C blue No. 1 aluminium lake
A protocol to evaluate the ocular irritation, staining, and embedding potential of FD&C colours (Yellow No. 5, Blue No. 1, Blue No. 1 Aluminium Lake) produced by repeated topical application to rabbit eyes is described. Test materials (3%, w/v in aqueous vehicle) were administered once daily, fo...
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| Veröffentlicht in: | Food and chemical toxicology 1992-12, Vol.30 (12), p.1051-1055 |
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| container_title | Food and chemical toxicology |
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| creator | GETTINGS, S. D BLASZCAK, D. L RODDY, M. T CURRY, A. S MCEWEN, G. N |
| description | A protocol to evaluate the ocular irritation, staining, and embedding potential of FD&C colours (Yellow No. 5, Blue No. 1, Blue No. 1 Aluminium Lake) produced by repeated topical application to rabbit eyes is described. Test materials (3%, w/v in aqueous vehicle) were administered once daily, for a total of 21 days, to the conjunctival sac of the right eye of New Zealand White Rabbits (6 of each sex per group) at a dose volume of 30 microliters. Control animals (6 of each sex) received 30 microliters of the vehicle daily. All animals survived and were free of significant clinical signs of toxicity throughout the study. Ophthalmoscopic examinations revealed that all animals were free of abnormalities considered to be of clinical importance; all animals were free of significant signs of ocular irritation, staining and particle embedment. The results of this study support the safe use of these materials in consumer products intended for use in the eye area. |
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Ophthalmoscopic examinations revealed that all animals were free of abnormalities considered to be of clinical importance; all animals were free of significant signs of ocular irritation, staining and particle embedment. The results of this study support the safe use of these materials in consumer products intended for use in the eye area.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>PMID: 1473799</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Science</publisher><subject>Animals ; Benzenesulfonates - toxicity ; Biological and medical sciences ; Body Weight - drug effects ; Conjunctiva - drug effects ; Cornea - drug effects ; Domestic and cosmetic products toxicology ; Female ; Male ; Medical sciences ; Rabbits ; Tartrazine - toxicity ; Toxicology</subject><ispartof>Food and chemical toxicology, 1992-12, Vol.30 (12), p.1051-1055</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4502583$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1473799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GETTINGS, S. 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N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the cumulative (repeated application) eye irritation and corneal staining potential of FD&C yellow No. 5, FD&C blue No. 1 and FD&C blue No. 1 aluminium lake</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>1992-12</date><risdate>1992</risdate><volume>30</volume><issue>12</issue><spage>1051</spage><epage>1055</epage><pages>1051-1055</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>A protocol to evaluate the ocular irritation, staining, and embedding potential of FD&C colours (Yellow No. 5, Blue No. 1, Blue No. 1 Aluminium Lake) produced by repeated topical application to rabbit eyes is described. Test materials (3%, w/v in aqueous vehicle) were administered once daily, for a total of 21 days, to the conjunctival sac of the right eye of New Zealand White Rabbits (6 of each sex per group) at a dose volume of 30 microliters. Control animals (6 of each sex) received 30 microliters of the vehicle daily. All animals survived and were free of significant clinical signs of toxicity throughout the study. Ophthalmoscopic examinations revealed that all animals were free of abnormalities considered to be of clinical importance; all animals were free of significant signs of ocular irritation, staining and particle embedment. The results of this study support the safe use of these materials in consumer products intended for use in the eye area.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Science</pub><pmid>1473799</pmid><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 1992-12, Vol.30 (12), p.1051-1055 |
| issn | 0278-6915 1873-6351 |
| language | eng |
| recordid | cdi_pubmed_primary_1473799 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Benzenesulfonates - toxicity Biological and medical sciences Body Weight - drug effects Conjunctiva - drug effects Cornea - drug effects Domestic and cosmetic products toxicology Female Male Medical sciences Rabbits Tartrazine - toxicity Toxicology |
| title | Evaluation of the cumulative (repeated application) eye irritation and corneal staining potential of FD&C yellow No. 5, FD&C blue No. 1 and FD&C blue No. 1 aluminium lake |
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