B-Endorphin Response to a Low Dosage of Human Corticotropin Releasing Hormone During Metyrapone Administration in Depression
This study defines the pituitary B-endorphin (BE) secretory response to a low dosage (0.3ug/kg) of human corticotropin releasing hormone (CRH) in depressed patients and normal controls pretreated with metyrapone. We find no difference in the B-endorphin response to CRH in depressed subjects without...
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| Veröffentlicht in: | Endocrine research 1992-01, Vol.18 (4), p.241-260 |
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| container_title | Endocrine research |
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| creator | Lisansky, Jonathan Hauger, Richard Strassman, Rick Dorin, Rick Meikle, A. W. Brazis, Madelyn Qualls, Clifford Turkin, Alan |
| description | This study defines the pituitary B-endorphin (BE) secretory response to a low dosage (0.3ug/kg) of human corticotropin releasing hormone (CRH) in depressed patients and normal controls pretreated with metyrapone. We find no difference in the B-endorphin response to CRH in depressed subjects without evidence of HPA overactivity, compared with controls. This finding is contrasted with other data demonstrating a blunted B-endorphin response to CRH in depressives. The influence of metyrapone pretreatment on the pituitary B-endorphin response to CRH through a mechanism that minimizes the impact of cortisol negative feedback is discussed. Future studies which include low dose CRH infusion both in the presence and in the absence of metyrapone pretreatment will help investigate alterations in the regulation of pituitary B-endorphin secretion in depression including the possibility of increased pituitary sensitivity to the negative fast feedback of cortisol. |
| doi_str_mv | 10.1080/07435809209111035 |
| format | Article |
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W. ; Brazis, Madelyn ; Qualls, Clifford ; Turkin, Alan</creator><creatorcontrib>Lisansky, Jonathan ; Hauger, Richard ; Strassman, Rick ; Dorin, Rick ; Meikle, A. W. ; Brazis, Madelyn ; Qualls, Clifford ; Turkin, Alan</creatorcontrib><description>This study defines the pituitary B-endorphin (BE) secretory response to a low dosage (0.3ug/kg) of human corticotropin releasing hormone (CRH) in depressed patients and normal controls pretreated with metyrapone. We find no difference in the B-endorphin response to CRH in depressed subjects without evidence of HPA overactivity, compared with controls. This finding is contrasted with other data demonstrating a blunted B-endorphin response to CRH in depressives. The influence of metyrapone pretreatment on the pituitary B-endorphin response to CRH through a mechanism that minimizes the impact of cortisol negative feedback is discussed. Future studies which include low dose CRH infusion both in the presence and in the absence of metyrapone pretreatment will help investigate alterations in the regulation of pituitary B-endorphin secretion in depression including the possibility of increased pituitary sensitivity to the negative fast feedback of cortisol.</description><identifier>ISSN: 0743-5800</identifier><identifier>EISSN: 1532-4206</identifier><identifier>DOI: 10.1080/07435809209111035</identifier><identifier>PMID: 1473519</identifier><identifier>CODEN: ENRSE8</identifier><language>eng</language><publisher>Monticello, NY: Informa Healthcare USA, Inc</publisher><subject>Adrenal Glands - physiopathology ; Adult and adolescent clinical studies ; beta-Endorphin - secretion ; Biological and medical sciences ; Corticotropin-Releasing Hormone ; Depression ; Depressive Disorder - physiopathology ; Female ; Humans ; Hydrocortisone - blood ; Hydrocortisone - urine ; Hypothalamus - physiopathology ; Kinetics ; Male ; Medical sciences ; Metyrapone ; Mood disorders ; Pituitary Gland - physiopathology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry</subject><ispartof>Endocrine research, 1992-01, Vol.18 (4), p.241-260</ispartof><rights>1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1992</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-878ad4f4ec32b8ee28ef241330b7f0480eef8f22ddbc5c9a6a04194e1bb0752b3</citedby><cites>FETCH-LOGICAL-c430t-878ad4f4ec32b8ee28ef241330b7f0480eef8f22ddbc5c9a6a04194e1bb0752b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/07435809209111035$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/07435809209111035$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4461073$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1473519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lisansky, Jonathan</creatorcontrib><creatorcontrib>Hauger, Richard</creatorcontrib><creatorcontrib>Strassman, Rick</creatorcontrib><creatorcontrib>Dorin, Rick</creatorcontrib><creatorcontrib>Meikle, A. W.</creatorcontrib><creatorcontrib>Brazis, Madelyn</creatorcontrib><creatorcontrib>Qualls, Clifford</creatorcontrib><creatorcontrib>Turkin, Alan</creatorcontrib><title>B-Endorphin Response to a Low Dosage of Human Corticotropin Releasing Hormone During Metyrapone Administration in Depression</title><title>Endocrine research</title><addtitle>Endocr Res</addtitle><description>This study defines the pituitary B-endorphin (BE) secretory response to a low dosage (0.3ug/kg) of human corticotropin releasing hormone (CRH) in depressed patients and normal controls pretreated with metyrapone. We find no difference in the B-endorphin response to CRH in depressed subjects without evidence of HPA overactivity, compared with controls. This finding is contrasted with other data demonstrating a blunted B-endorphin response to CRH in depressives. The influence of metyrapone pretreatment on the pituitary B-endorphin response to CRH through a mechanism that minimizes the impact of cortisol negative feedback is discussed. Future studies which include low dose CRH infusion both in the presence and in the absence of metyrapone pretreatment will help investigate alterations in the regulation of pituitary B-endorphin secretion in depression including the possibility of increased pituitary sensitivity to the negative fast feedback of cortisol.</description><subject>Adrenal Glands - physiopathology</subject><subject>Adult and adolescent clinical studies</subject><subject>beta-Endorphin - secretion</subject><subject>Biological and medical sciences</subject><subject>Corticotropin-Releasing Hormone</subject><subject>Depression</subject><subject>Depressive Disorder - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Hydrocortisone - urine</subject><subject>Hypothalamus - physiopathology</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metyrapone</subject><subject>Mood disorders</subject><subject>Pituitary Gland - physiopathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><issn>0743-5800</issn><issn>1532-4206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kNGK1DAUhoMo67j6AF4IuRDvup406bRFb3Zndh1hRBC9LqfpyU6WNqlJyjLgw9txRkWEvQon__cfko-xlwIuBFTwFkoliwrqHGohBMjiEVuIQuaZymH5mC0OeTYD8JQ9i_EOQEgAecbOhCplIeoF-3GVXbvOh3FnHf9CcfQuEk-eI9_6e772EW-Je8M304COr3xIVvsU_PiL7wmjdbd848PgHfH1FA7jJ0r7gOPh5rIbrLMxBUzWOz631jQGinGenrMnBvtIL07nOft2c_11tcm2nz98XF1uM60kpKwqK-yUUaRl3lZEeUUmV0JKaEsDqgIiU5k877pWF7rGJYIStSLRtlAWeSvP2Zvj3jH47xPF1Aw2aup7dOSn2JRSCQWwnEFxBHXwMQYyzRjsgGHfCGgOxpv_jM-dV6flUztQ97dxVDznr085Ro29Cei0jX8wpZYCSjlj74-YdWaWifc-9F2TcN_78LsjH3rFu3_qO8I-7TQGau78FNys94E__AReT675</recordid><startdate>19920101</startdate><enddate>19920101</enddate><creator>Lisansky, Jonathan</creator><creator>Hauger, Richard</creator><creator>Strassman, Rick</creator><creator>Dorin, Rick</creator><creator>Meikle, A. W.</creator><creator>Brazis, Madelyn</creator><creator>Qualls, Clifford</creator><creator>Turkin, Alan</creator><general>Informa Healthcare USA, Inc</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920101</creationdate><title>B-Endorphin Response to a Low Dosage of Human Corticotropin Releasing Hormone During Metyrapone Administration in Depression</title><author>Lisansky, Jonathan ; Hauger, Richard ; Strassman, Rick ; Dorin, Rick ; Meikle, A. W. ; Brazis, Madelyn ; Qualls, Clifford ; Turkin, Alan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-878ad4f4ec32b8ee28ef241330b7f0480eef8f22ddbc5c9a6a04194e1bb0752b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adrenal Glands - physiopathology</topic><topic>Adult and adolescent clinical studies</topic><topic>beta-Endorphin - secretion</topic><topic>Biological and medical sciences</topic><topic>Corticotropin-Releasing Hormone</topic><topic>Depression</topic><topic>Depressive Disorder - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Hydrocortisone - urine</topic><topic>Hypothalamus - physiopathology</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metyrapone</topic><topic>Mood disorders</topic><topic>Pituitary Gland - physiopathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lisansky, Jonathan</creatorcontrib><creatorcontrib>Hauger, Richard</creatorcontrib><creatorcontrib>Strassman, Rick</creatorcontrib><creatorcontrib>Dorin, Rick</creatorcontrib><creatorcontrib>Meikle, A. W.</creatorcontrib><creatorcontrib>Brazis, Madelyn</creatorcontrib><creatorcontrib>Qualls, Clifford</creatorcontrib><creatorcontrib>Turkin, Alan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lisansky, Jonathan</au><au>Hauger, Richard</au><au>Strassman, Rick</au><au>Dorin, Rick</au><au>Meikle, A. W.</au><au>Brazis, Madelyn</au><au>Qualls, Clifford</au><au>Turkin, Alan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>B-Endorphin Response to a Low Dosage of Human Corticotropin Releasing Hormone During Metyrapone Administration in Depression</atitle><jtitle>Endocrine research</jtitle><addtitle>Endocr Res</addtitle><date>1992-01-01</date><risdate>1992</risdate><volume>18</volume><issue>4</issue><spage>241</spage><epage>260</epage><pages>241-260</pages><issn>0743-5800</issn><eissn>1532-4206</eissn><coden>ENRSE8</coden><abstract>This study defines the pituitary B-endorphin (BE) secretory response to a low dosage (0.3ug/kg) of human corticotropin releasing hormone (CRH) in depressed patients and normal controls pretreated with metyrapone. We find no difference in the B-endorphin response to CRH in depressed subjects without evidence of HPA overactivity, compared with controls. This finding is contrasted with other data demonstrating a blunted B-endorphin response to CRH in depressives. The influence of metyrapone pretreatment on the pituitary B-endorphin response to CRH through a mechanism that minimizes the impact of cortisol negative feedback is discussed. Future studies which include low dose CRH infusion both in the presence and in the absence of metyrapone pretreatment will help investigate alterations in the regulation of pituitary B-endorphin secretion in depression including the possibility of increased pituitary sensitivity to the negative fast feedback of cortisol.</abstract><cop>Monticello, NY</cop><pub>Informa Healthcare USA, Inc</pub><pmid>1473519</pmid><doi>10.1080/07435809209111035</doi><tpages>20</tpages></addata></record> |
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| ispartof | Endocrine research, 1992-01, Vol.18 (4), p.241-260 |
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| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adrenal Glands - physiopathology Adult and adolescent clinical studies beta-Endorphin - secretion Biological and medical sciences Corticotropin-Releasing Hormone Depression Depressive Disorder - physiopathology Female Humans Hydrocortisone - blood Hydrocortisone - urine Hypothalamus - physiopathology Kinetics Male Medical sciences Metyrapone Mood disorders Pituitary Gland - physiopathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
| title | B-Endorphin Response to a Low Dosage of Human Corticotropin Releasing Hormone During Metyrapone Administration in Depression |
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