Thiochrome Enhances Acetylcholine Affinity at Muscarinic M4 Receptors: Receptor Subtype Selectivity via Cooperativity Rather than Affinity

Thiochrome (2,7-dimethyl-5 H -thiachromine-8-ethanol), an oxidation product and metabolite of thiamine, has little effect on the equilibrium binding of l -[ 3 H] N -methyl scopolamine ([ 3 H]NMS) to the five human muscarinic receptor subtypes (M 1 –M 5 ) at concentrations up to 0.3 mM. In contrast...

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