Tamoxifen is an estrogen antagonist on gonadotropin secretion and responsiveness of the hypothalamic-pituitary- adrenal axis in female monkeys

The selective estrogen receptor modulator, tamoxifen, effectively slows the progression of estrogen-positive breast cancer and reduces the possibility of this cancer developing in women at high risk. Despite the widespread acceptance of tamoxifen as a therapeutic agent for this disease, its effects...

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Veröffentlicht in:	Endocrine 2003-12, Vol.22 (3), p.305-316
Hauptverfasser:	Wilson, M E, Mook, D, Graves, F, Felger, J, Bielsky, I F, Wallen, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - blood Adrenocorticotropic Hormone - secretion Animals Area Under Curve Corticotropin-Releasing Hormone - metabolism Dexamethasone - pharmacology Drug Interactions Estradiol - blood Estradiol - pharmacology Estrogen Receptor Modulators - pharmacology Feedback, Physiological - drug effects Feedback, Physiological - physiology Female Gonadotropins - secretion Hydrocortisone - blood Hydrocortisone - secretion Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiology Luteinizing Hormone - antagonists & inhibitors Luteinizing Hormone - blood Luteinizing Hormone - metabolism Luteinizing Hormone - secretion Macaca mulatta - metabolism Macaca mulatta - physiology Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - physiology Random Allocation Selective Estrogen Receptor Modulators - pharmacology Tamoxifen - pharmacology
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