Coenzyme Q10 reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potential

Defects in mitochondrial energy metabolism due to respiratory chain disorders lead to a decrease in mitochondrial membrane potential (ΔΨm) and induce apoptosis. Since coenzyme Q10 (CoQ10) plays a dual role as an antioxidant and bioenergetic agent in the respiratory chain, it has attracted increasing...

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Veröffentlicht in:	BioFactors (Oxford) 2003, Vol.18 (1-4), p.65-72
Hauptverfasser:	Menke, T., Gille, G., Reber, F., Janetzky, B., Andler, W., Funk, R. H. W., Reichmann, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology apoptosis Apoptosis - drug effects Benzimidazoles Carbocyanines coenzyme Q10 Coenzymes Cytoprotection Electron Transport - drug effects Electron Transport Complex I - antagonists & inhibitors Energy Metabolism - drug effects Enzyme Inhibitors - toxicity Fluorescent Dyes Humans JC-1 Membrane Potentials - drug effects Mitochondria - metabolism Mitochondria - ultrastructure mitochondrial membrane potential Neuroblastoma Neurons - drug effects Neurons - ultrastructure Rotenone - toxicity SH-SY5Y Tumor Cells, Cultured Ubiquinone - analogs & derivatives Ubiquinone - pharmacology
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