Expression studies of the PIS-regulated genes suggest different mechanisms of sex determination within mammals

In mammals, the Y-located SRY gene is known to induce testis formation from the indifferent gonad. A related gene, SOX9, also plays a critical role in testis differentiation in mammals, in birds and reptiles. It is now assumed that SRY acts upstream of SOX9 in the sex determination cascade, but the...

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Veröffentlicht in:	Cytogenetic and genome research 2003-01, Vol.101 (3-4), p.199-205
Hauptverfasser:	Pannetier, M., Servel, N., Cocquet, J., Besnard, N., Cotinot, C., Pailhoux, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotechnology Capra Disorders of Sex Development DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Female Forkhead Box Protein L2 Forkhead Transcription Factors FOXL gene Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene therapy Goats Gonads - anatomy & histology Gonads - metabolism Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Life Sciences Male Mammals - genetics Mice Mutation Nuclear Proteins Regulatory Sequences, Nucleic Acid Sex Determination Processes Sex-Determining Region Y Protein SOX9 gene Species Specificity Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic
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