Expression studies of the PIS-regulated genes suggest different mechanisms of sex determination within mammals
In mammals, the Y-located SRY gene is known to induce testis formation from the indifferent gonad. A related gene, SOX9, also plays a critical role in testis differentiation in mammals, in birds and reptiles. It is now assumed that SRY acts upstream of SOX9 in the sex determination cascade, but the...
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| creator | Pannetier, M. Servel, N. Cocquet, J. Besnard, N. Cotinot, C. Pailhoux, E. |
| description | In mammals, the Y-located SRY gene is known to induce testis formation from the indifferent gonad. A related gene, SOX9, also plays a critical role in testis differentiation in mammals, in birds and reptiles. It is now assumed that SRY acts upstream of SOX9 in the sex determination cascade, but the regulatory link which should exist between these two genes remains unknown. Studies on XX sex reversal in polled goats (PIS mutation: Polled Intersex Syndrome) have led to the discovery of a female-specific locus crucial for ovarian differentiation. This genomic region is composed of at least two genes, FOXL2 and PISRT1, which share a common transcriptional regulatory region, PIS. In this review, we present the expression pattern of these PIS-regulated genes in mice. The FOXL2 expression profile of mice is similar to that described in goats in accordance with a conserved role of this ovarian differentiating gene in mammals. On the contrary, the PISRT1 expression profile is different between mice and goats, suggesting different mechanisms of the primary switch in the testis determination process within mammals. A model based on two different modes of SOX9 regulation in mice and other mammals is proposed in order to integrate our results into the current scheme of gonad differentiation. |
| doi_str_mv | 10.1159/000074337 |
| format | Article |
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A related gene, SOX9, also plays a critical role in testis differentiation in mammals, in birds and reptiles. It is now assumed that SRY acts upstream of SOX9 in the sex determination cascade, but the regulatory link which should exist between these two genes remains unknown. Studies on XX sex reversal in polled goats (PIS mutation: Polled Intersex Syndrome) have led to the discovery of a female-specific locus crucial for ovarian differentiation. This genomic region is composed of at least two genes, FOXL2 and PISRT1, which share a common transcriptional regulatory region, PIS. In this review, we present the expression pattern of these PIS-regulated genes in mice. The FOXL2 expression profile of mice is similar to that described in goats in accordance with a conserved role of this ovarian differentiating gene in mammals. On the contrary, the PISRT1 expression profile is different between mice and goats, suggesting different mechanisms of the primary switch in the testis determination process within mammals. A model based on two different modes of SOX9 regulation in mice and other mammals is proposed in order to integrate our results into the current scheme of gonad differentiation. </description><identifier>ISSN: 1424-8581</identifier><identifier>ISBN: 3805576889</identifier><identifier>ISBN: 9783805576888</identifier><identifier>EISSN: 1424-859X</identifier><identifier>EISBN: 3318010545</identifier><identifier>EISBN: 9783318010541</identifier><identifier>DOI: 10.1159/000074337</identifier><identifier>PMID: 14684983</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Animals ; Biological and medical sciences ; Biotechnology ; Capra ; Disorders of Sex Development ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; DNA-Binding Proteins - physiology ; Female ; Forkhead Box Protein L2 ; Forkhead Transcription Factors ; FOXL gene ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Gene therapy ; Goats ; Gonads - anatomy & histology ; Gonads - metabolism ; Health. Pharmaceutical industry ; Industrial applications and implications. Economical aspects ; Life Sciences ; Male ; Mammals - genetics ; Mice ; Mutation ; Nuclear Proteins ; Regulatory Sequences, Nucleic Acid ; Sex Determination Processes ; Sex-Determining Region Y Protein ; SOX9 gene ; Species Specificity ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transcription, Genetic</subject><ispartof>Cytogenetic and genome research, 2003-01, Vol.101 (3-4), p.199-205</ispartof><rights>2003 S. Karger AG, Basel</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2003 S. Karger AG, Basel</rights><rights>Copyright (c) 2003 S. Karger AG, Basel</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-9b1aed7c20652e3e6a4ab86c5a87c6794e04aec4156b20b764cf0ce5d1a0452a3</citedby><cites>FETCH-LOGICAL-c578t-9b1aed7c20652e3e6a4ab86c5a87c6794e04aec4156b20b764cf0ce5d1a0452a3</cites><orcidid>0000-0002-5826-619X ; 0000-0001-8012-9143</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,309,310,314,776,780,785,786,881,2422,23910,23911,25119,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15386611$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14684983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02675835$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Pannetier, M.</creatorcontrib><creatorcontrib>Servel, N.</creatorcontrib><creatorcontrib>Cocquet, J.</creatorcontrib><creatorcontrib>Besnard, N.</creatorcontrib><creatorcontrib>Cotinot, C.</creatorcontrib><creatorcontrib>Pailhoux, E.</creatorcontrib><title>Expression studies of the PIS-regulated genes suggest different mechanisms of sex determination within mammals</title><title>Cytogenetic and genome research</title><addtitle>Cytogenet Genome Res</addtitle><description>In mammals, the Y-located SRY gene is known to induce testis formation from the indifferent gonad. A related gene, SOX9, also plays a critical role in testis differentiation in mammals, in birds and reptiles. It is now assumed that SRY acts upstream of SOX9 in the sex determination cascade, but the regulatory link which should exist between these two genes remains unknown. Studies on XX sex reversal in polled goats (PIS mutation: Polled Intersex Syndrome) have led to the discovery of a female-specific locus crucial for ovarian differentiation. This genomic region is composed of at least two genes, FOXL2 and PISRT1, which share a common transcriptional regulatory region, PIS. In this review, we present the expression pattern of these PIS-regulated genes in mice. The FOXL2 expression profile of mice is similar to that described in goats in accordance with a conserved role of this ovarian differentiating gene in mammals. On the contrary, the PISRT1 expression profile is different between mice and goats, suggesting different mechanisms of the primary switch in the testis determination process within mammals. A model based on two different modes of SOX9 regulation in mice and other mammals is proposed in order to integrate our results into the current scheme of gonad differentiation. </description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Capra</subject><subject>Disorders of Sex Development</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Female</subject><subject>Forkhead Box Protein L2</subject><subject>Forkhead Transcription Factors</subject><subject>FOXL gene</subject><subject>Fundamental and applied biological sciences. 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A related gene, SOX9, also plays a critical role in testis differentiation in mammals, in birds and reptiles. It is now assumed that SRY acts upstream of SOX9 in the sex determination cascade, but the regulatory link which should exist between these two genes remains unknown. Studies on XX sex reversal in polled goats (PIS mutation: Polled Intersex Syndrome) have led to the discovery of a female-specific locus crucial for ovarian differentiation. This genomic region is composed of at least two genes, FOXL2 and PISRT1, which share a common transcriptional regulatory region, PIS. In this review, we present the expression pattern of these PIS-regulated genes in mice. The FOXL2 expression profile of mice is similar to that described in goats in accordance with a conserved role of this ovarian differentiating gene in mammals. On the contrary, the PISRT1 expression profile is different between mice and goats, suggesting different mechanisms of the primary switch in the testis determination process within mammals. A model based on two different modes of SOX9 regulation in mice and other mammals is proposed in order to integrate our results into the current scheme of gonad differentiation. </abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>14684983</pmid><doi>10.1159/000074337</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5826-619X</orcidid><orcidid>https://orcid.org/0000-0001-8012-9143</orcidid></addata></record> |
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| subjects | Animals Biological and medical sciences Biotechnology Capra Disorders of Sex Development DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Female Forkhead Box Protein L2 Forkhead Transcription Factors FOXL gene Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene therapy Goats Gonads - anatomy & histology Gonads - metabolism Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Life Sciences Male Mammals - genetics Mice Mutation Nuclear Proteins Regulatory Sequences, Nucleic Acid Sex Determination Processes Sex-Determining Region Y Protein SOX9 gene Species Specificity Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic |
| title | Expression studies of the PIS-regulated genes suggest different mechanisms of sex determination within mammals |
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