Evidence for Golgi bodies in proposed 'Golgi-lacking' lineages
Golgi bodies are nearly ubiquitous in eukaryotic cells. The apparent lack of such structures in certain eukaryotic lineages might be taken to mean that these protists evolved prior to the acquisition of the Golgi, and it raises questions of how these organisms function in the absence of this crucial...
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| Veröffentlicht in: | Proceedings of the Royal Society. B, Biological sciences Biological sciences, 2003-11, Vol.270 (Suppl 2), p.S168-S171 |
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| container_title | Proceedings of the Royal Society. B, Biological sciences |
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| creator | Dacks, Joel B. Davis, Lesley A. M. Sjögren, Åsa M. Andersson, Jan O. Roger, Andrew J. Doolittle, W. Ford |
| description | Golgi bodies are nearly ubiquitous in eukaryotic cells. The apparent lack of such structures in certain eukaryotic lineages might be taken to mean that these protists evolved prior to the acquisition of the Golgi, and it raises questions of how these organisms function in the absence of this crucial organelle. Here, we report gene sequences from five proposed 'Golgi-lacking' organisms (Giardia intestinalis, Spironucleus barkhanus, Entamoeba histolytica, Naegleria gruberi and Mastigamoeba balamuthi). BLAST and phylogenetic analyses show these genes to be homologous to those encoding components of the retromer, coatomer and adaptin complexes, all of which have Golgi-related functions in mammals and yeast. This is, to our knowledge, the first molecular evidence for Golgi bodies in two major eukaryotic lineages (the pelobionts and heteroloboseids). This substantiates the suggestion that there are no extant primitively 'Golgi-lacking' lineages, and that this apparatus was present in the last common eukaryotic ancestor, but has been altered beyond recognition several times. |
| doi_str_mv | 10.1098/rsbl.2003.0058 |
| format | Article |
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M. ; Sjögren, Åsa M. ; Andersson, Jan O. ; Roger, Andrew J. ; Doolittle, W. Ford</creator><creatorcontrib>Dacks, Joel B. ; Davis, Lesley A. M. ; Sjögren, Åsa M. ; Andersson, Jan O. ; Roger, Andrew J. ; Doolittle, W. Ford</creatorcontrib><description>Golgi bodies are nearly ubiquitous in eukaryotic cells. The apparent lack of such structures in certain eukaryotic lineages might be taken to mean that these protists evolved prior to the acquisition of the Golgi, and it raises questions of how these organisms function in the absence of this crucial organelle. Here, we report gene sequences from five proposed 'Golgi-lacking' organisms (Giardia intestinalis, Spironucleus barkhanus, Entamoeba histolytica, Naegleria gruberi and Mastigamoeba balamuthi). BLAST and phylogenetic analyses show these genes to be homologous to those encoding components of the retromer, coatomer and adaptin complexes, all of which have Golgi-related functions in mammals and yeast. This is, to our knowledge, the first molecular evidence for Golgi bodies in two major eukaryotic lineages (the pelobionts and heteroloboseids). This substantiates the suggestion that there are no extant primitively 'Golgi-lacking' lineages, and that this apparatus was present in the last common eukaryotic ancestor, but has been altered beyond recognition several times.</description><identifier>ISSN: 0962-8452</identifier><identifier>EISSN: 1471-2954</identifier><identifier>DOI: 10.1098/rsbl.2003.0058</identifier><identifier>PMID: 14667372</identifier><language>eng</language><publisher>England: The Royal Society</publisher><subject>Amino Acid Sequence ; Animals ; Archezoa ; Blasts ; Databases, Nucleic Acid ; Endocytosis ; Endomembrane ; Entamoeba histolytica ; Eukaryota - genetics ; Eukaryotic cells ; Evolution ; Evolution, Molecular ; Fungi ; Giardia intestinalis ; Golgi apparatus ; Golgi Apparatus - genetics ; Golgi Apparatus - physiology ; Mastigamoeba balamuthi ; Mitochondria ; Molecular Sequence Data ; Naegleria gruberi ; Organelle ; Organelles ; Phylogeny ; Secretion ; Sequence Alignment ; Sequence Analysis, DNA ; Spironucleus barkhanus ; Taxa ; Yeasts</subject><ispartof>Proceedings of the Royal Society. 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BLAST and phylogenetic analyses show these genes to be homologous to those encoding components of the retromer, coatomer and adaptin complexes, all of which have Golgi-related functions in mammals and yeast. This is, to our knowledge, the first molecular evidence for Golgi bodies in two major eukaryotic lineages (the pelobionts and heteroloboseids). 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B, Biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dacks, Joel B.</au><au>Davis, Lesley A. M.</au><au>Sjögren, Åsa M.</au><au>Andersson, Jan O.</au><au>Roger, Andrew J.</au><au>Doolittle, W. Ford</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for Golgi bodies in proposed 'Golgi-lacking' lineages</atitle><jtitle>Proceedings of the Royal Society. B, Biological sciences</jtitle><addtitle>Proc Biol Sci</addtitle><date>2003-11-07</date><risdate>2003</risdate><volume>270</volume><issue>Suppl 2</issue><spage>S168</spage><epage>S171</epage><pages>S168-S171</pages><issn>0962-8452</issn><eissn>1471-2954</eissn><abstract>Golgi bodies are nearly ubiquitous in eukaryotic cells. 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| ispartof | Proceedings of the Royal Society. B, Biological sciences, 2003-11, Vol.270 (Suppl 2), p.S168-S171 |
| issn | 0962-8452 1471-2954 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central |
| subjects | Amino Acid Sequence Animals Archezoa Blasts Databases, Nucleic Acid Endocytosis Endomembrane Entamoeba histolytica Eukaryota - genetics Eukaryotic cells Evolution Evolution, Molecular Fungi Giardia intestinalis Golgi apparatus Golgi Apparatus - genetics Golgi Apparatus - physiology Mastigamoeba balamuthi Mitochondria Molecular Sequence Data Naegleria gruberi Organelle Organelles Phylogeny Secretion Sequence Alignment Sequence Analysis, DNA Spironucleus barkhanus Taxa Yeasts |
| title | Evidence for Golgi bodies in proposed 'Golgi-lacking' lineages |
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