Pulmonary Effects and Clearance After Long-Term Inhalation of Potassium Octatitanate Whiskers in Rats

The pulmonary effects of long-term inhalation of potassium octatitanate whisker (PT1), one of the durable man-made fibers (MMFs), were examined in rats. Male Wistar rats were exposed to PT1 by inhalation for 6 h/day, 5 days/wk for 1 yr. The daily average exposure concentration of PT1 aerosol was 2.2...

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Veröffentlicht in:	Inhalation toxicology 2003-12, Vol.15 (14), p.1421-1434
Hauptverfasser:	Yamato, Hiroshi, Oyabu, Takako, Ogami, Akira, Morimoto, Yasuo, Higashi, Toshiaki, Tanaka, Isamu, Ishimatsu, Sumiyo, Hori, Hajime, Kasai, Takahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - etiology Adenoma - veterinary Administration, Inhalation Aerosols Animals Animals, Newborn Lung - pathology Lung Neoplasms - etiology Lung Neoplasms - veterinary Male Manufactured Materials Mineral Fibers Minerals potassium octatitanate Rats Rats, Wistar Tissue Distribution Titanium - pharmacokinetics Titanium - toxicity
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