Serine 447 in the Carboxyl Tail of Human VPAC1 Receptor Is Crucial for Agonist-Induced Desensitization but Not Internalization of the Receptor

The VPAC 1 receptor for vasoactive intestinal peptide (VIP) belongs to the class II family of G protein-coupled receptors and is coupled to Gs protein/adenylyl cyclase. We assessed whether 10 different Ser/Thr residues in human VPAC 1 receptor intracellular domains play a role in the process of VIP-...

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Veröffentlicht in:	Molecular pharmacology 2003-12, Vol.64 (6), p.1565
Hauptverfasser:	Jean-Claude Marie, Christiane Rouyer-Fessard, Alain Couvineau, Pascal Nicole, HÃ©lÃ¨ne Devaud, Jamel El Benna, Marc Laburthe
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence - genetics Animals CHO Cells Cricetinae Dose-Response Relationship, Drug Humans Molecular Sequence Data Peptide Fragments - genetics Peptide Fragments - metabolism Protein Structure, Tertiary - genetics Receptors, Vasoactive Intestinal Peptide - agonists Receptors, Vasoactive Intestinal Peptide - chemistry Receptors, Vasoactive Intestinal Peptide - genetics Receptors, Vasoactive Intestinal Peptide - metabolism Receptors, Vasoactive Intestinal Polypeptide, Type I Serine - chemistry Serine - genetics Serine - metabolism Vasoactive Intestinal Peptide - metabolism Vasoactive Intestinal Peptide - pharmacology
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