DNA Bending and Unbending by MutS Govern Mismatch Recognition and Specificity

DNA mismatch repair is central to the maintenance of genomic stability. It is initiated by the recognition of base-base mismatches and insertion/deletion loops by the family of MutS proteins. Subsequently, ATP induces a unique conformational change in the MutS-mismatch complex but not in the MutS-ho...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-12, Vol.100 (25), p.14822-14827
Hauptverfasser:	Wang, Hong, Yang, Yong, Schofield, Mark J., Du, Chunwei, Fridman, Yonatan, Lee, Susan D., Larson, Erik D., Drummond, James T., Alani, Eric, Hsieh, Peggy, Erie, Dorothy A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - chemistry Adenosine Triphosphate - chemistry atomic force microscopy Bacterial Proteins - chemistry Base Pair Mismatch Bending Binding Sites Biochemistry Biological Sciences Biophysics Crystal structure Crystallography, X-Ray Deoxyribonucleic acid Dimerization Dimers DNA DNA - chemistry DNA - metabolism DNA Fragmentation DNA mismatch repair DNA Repair DNA-Binding Proteins - chemistry Electrophoresis Escherichia coli - metabolism Escherichia coli Proteins Gels Genetics IDL lipoproteins Image Processing, Computer-Assisted Microscopy, Atomic Force mismatch repair Models, Chemical Models, Genetic MutS DNA Mismatch-Binding Protein MutS protein Normal Distribution Nucleic Acid Conformation Protein Binding Protein Conformation Proteins - chemistry Room temperature
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