The non-classical export routes: FGF1 and IL-1alpha point the way

Non-classical protein release independent of the ER-Golgi pathway has been reported for an increasing number of proteins lacking an N-terminal signal sequence. The export of FGF1 and IL-1alpha, two pro-angiogenic polypeptides, provides two such examples. In both cases, export is based on the Cu2+-de...

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Veröffentlicht in:	Journal of cell science 2003-12, Vol.116 (Pt 24), p.4871
Hauptverfasser:	Prudovsky, Igor, Mandinova, Anna, Soldi, Raffaella, Bagala, Cinzia, Graziani, Irene, Landriscina, Matteo, Tarantini, Francesca, Duarte, Maria, Bellum, Stephen, Doherty, Holly, Maciag, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Hypoxia - physiology Cell Membrane - metabolism Copper - metabolism Endoplasmic Reticulum - metabolism Fibroblast Growth Factor 1 - metabolism Humans Interleukin-1 - metabolism Membrane Fluidity - physiology Models, Structural Neovascularization, Pathologic - metabolism Protein Sorting Signals - physiology Protein Transport S100 Proteins
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