Nonorthologous Replacement of Lysyl-tRNA Synthetase Prevents Addition of Lysine Analogues to the Genetic Code

Insertion of lysine during protein synthesis depends on the enzyme lysyl-tRNA synthetase (LysRS), which exists in two unrelated forms, LysRS1 and LysRS2. LysRS1 has been found in most archaea and some bacteria, and LysRS2 has been found in eukarya, most bacteria, and a few archaea, but the two prote...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-11, Vol.100 (24), p.14351-14356
Hauptverfasser:	Jester, Brian C., Levengood, Jeffrey D., Roy, Hervé, Ibba, Michael, Devine, Kevin M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Bacillus subtilis Bacillus subtilis - drug effects Bacillus subtilis - enzymology Bacillus subtilis - genetics Bacteria Biological Sciences Borrelia burgdorferi Borrelia burgdorferi - drug effects Borrelia burgdorferi - enzymology Borrelia burgdorferi - genetics Cell growth Chromosomes Cysteine - analogs & derivatives Cysteine - pharmacology Drug Resistance, Bacterial - genetics Enzyme Inhibitors - pharmacology Enzymes Evolution, Molecular Genes Genes, Bacterial Genetic Code Genetics Genomics Isoenzymes - antagonists & inhibitors Isoenzymes - genetics Isoenzymes - metabolism Lysine - analogs & derivatives Lysine - metabolism Lysine-tRNA Ligase - antagonists & inhibitors Lysine-tRNA Ligase - genetics Lysine-tRNA Ligase - metabolism Microbiology Plasmids Ribonucleic acid RNA RNA, Transfer, Lys - metabolism S-(2-Aminoethyl)-L-cysteine Species Specificity Transfer RNA
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