Effects of a melanogenic bicyclic monoterpene diol on cell cycle, p53, TNF-α, and PGE2 are distinct from those of UVB

Purpose: Bicyclic monoterpene (BMT) diols are small‐molecule compounds that mimic ultraviolet radiation (UVR) by inducing melanogenesis. The objective of this study was to compare the effects of 2,2‐dimethyl‐3‐propanyldiol‐norbornane (AGI‐1140), a novel BMT diol, and ultraviolet B (UVB) on additiona...

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Veröffentlicht in:	Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2003-12, Vol.19 (6), p.295-302
Hauptverfasser:	Kraus, Eliyahu, Galvin, Jason W., Boumakis, Stavroula, Boamah, Ernest K., Canning, Matthew T., Yarosh, Daniel B., Brown, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western cell cycle Cell Cycle - drug effects Cell Cycle - radiation effects Cell Line, Tumor - drug effects Cell Line, Tumor - metabolism Cell Line, Tumor - radiation effects cytokine Dendrites - drug effects Dendrites - metabolism Dendrites - radiation effects Dermatology Dinoprostone - biosynthesis Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - radiation effects Enzyme-Linked Immunosorbent Assay Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - radiation effects Investigative techniques, diagnostic techniques (general aspects) keratinocyte Keratinocytes - drug effects Keratinocytes - metabolism Keratinocytes - radiation effects Medical sciences melanocyte Melanocytes - drug effects Melanocytes - metabolism Melanocytes - radiation effects Melanoma, Experimental - pathology Mice monoterpene Monoterpenes - administration & dosage Monoterpenes - pharmacology Nitric Oxide - biosynthesis Norbornanes - administration & dosage Norbornanes - pharmacology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques prostaglandin Skin Pigmentation - drug effects Skin Pigmentation - radiation effects Tumor Necrosis Factor-alpha - biosynthesis ultraviolet Ultraviolet Rays
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