Leptin Levels Increase during Flutamide Therapy in Women with Polycystic Ovary Syndrome
Aim: To evaluate the serum leptin levels and the effects of flutamide treatment on the leptin levels in women with polycystic ovary syndrome (PCOS). Methods: 20 women with PCOS and 20 controls were enrolled in the study. Leptin levels and leptin response to an oral glucose tolerance test were assess...
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| Veröffentlicht in: | Hormone research 2003-01, Vol.60 (5), p.232-236 |
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| container_title | Hormone research |
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| creator | Sahin, Ibrahim Serter, Rustu Karakurt, Feridun Demirbas, Berrin Guler, Serdar Culha, Cavit Taskapan, Cagatay Aral, Yalcin |
| description | Aim: To evaluate the serum leptin levels and the effects of flutamide treatment on the leptin levels in women with polycystic ovary syndrome (PCOS). Methods: 20 women with PCOS and 20 controls were enrolled in the study. Leptin levels and leptin response to an oral glucose tolerance test were assessed in both groups before and after a 4-week flutamide therapy period. Results: The leptin levels were similar in both groups at baseline. In the PCOS group, leptin levels and area under curve for leptin levels increased significantly after flutamide treatment. Conclusions: Women with PCOS had similar leptin levels to those of controls with similar age and body mass index. Flutamide treatment led to increased leptin levels and leptin responses to oral glucose tolerance tests in PCOS patients. Further studies are needed to gain insights into the clinical consequences of these effects of flutamide. |
| doi_str_mv | 10.1159/000074037 |
| format | Article |
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Methods: 20 women with PCOS and 20 controls were enrolled in the study. Leptin levels and leptin response to an oral glucose tolerance test were assessed in both groups before and after a 4-week flutamide therapy period. Results: The leptin levels were similar in both groups at baseline. In the PCOS group, leptin levels and area under curve for leptin levels increased significantly after flutamide treatment. Conclusions: Women with PCOS had similar leptin levels to those of controls with similar age and body mass index. Flutamide treatment led to increased leptin levels and leptin responses to oral glucose tolerance tests in PCOS patients. Further studies are needed to gain insights into the clinical consequences of these effects of flutamide.</description><identifier>ISSN: 1663-2818</identifier><identifier>ISSN: 0301-0163</identifier><identifier>EISSN: 1663-2826</identifier><identifier>DOI: 10.1159/000074037</identifier><identifier>PMID: 14614228</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adolescent ; Adult ; Androgen Antagonists - therapeutic use ; Anthropometry ; Area Under Curve ; Blood Glucose - metabolism ; Case-Control Studies ; Female ; Flutamide - therapeutic use ; Glucose Tolerance Test ; Hormones - blood ; Humans ; Leptin - blood ; Original Paper ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - drug therapy</subject><ispartof>Hormone research, 2003-01, Vol.60 (5), p.232-236</ispartof><rights>2003 S. Karger AG, Basel</rights><rights>Copyright 2003 S. Karger AG, Basel</rights><rights>Copyright (c) 2003 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-97f36f901738764332665e62d189edb61d6fe81e31e1c48dae78508c7a789b8b3</citedby><cites>FETCH-LOGICAL-c356t-97f36f901738764332665e62d189edb61d6fe81e31e1c48dae78508c7a789b8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14614228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sahin, Ibrahim</creatorcontrib><creatorcontrib>Serter, Rustu</creatorcontrib><creatorcontrib>Karakurt, Feridun</creatorcontrib><creatorcontrib>Demirbas, Berrin</creatorcontrib><creatorcontrib>Guler, Serdar</creatorcontrib><creatorcontrib>Culha, Cavit</creatorcontrib><creatorcontrib>Taskapan, Cagatay</creatorcontrib><creatorcontrib>Aral, Yalcin</creatorcontrib><title>Leptin Levels Increase during Flutamide Therapy in Women with Polycystic Ovary Syndrome</title><title>Hormone research</title><addtitle>Horm Res Paediatr</addtitle><description>Aim: To evaluate the serum leptin levels and the effects of flutamide treatment on the leptin levels in women with polycystic ovary syndrome (PCOS). Methods: 20 women with PCOS and 20 controls were enrolled in the study. Leptin levels and leptin response to an oral glucose tolerance test were assessed in both groups before and after a 4-week flutamide therapy period. Results: The leptin levels were similar in both groups at baseline. In the PCOS group, leptin levels and area under curve for leptin levels increased significantly after flutamide treatment. Conclusions: Women with PCOS had similar leptin levels to those of controls with similar age and body mass index. Flutamide treatment led to increased leptin levels and leptin responses to oral glucose tolerance tests in PCOS patients. Further studies are needed to gain insights into the clinical consequences of these effects of flutamide.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Androgen Antagonists - therapeutic use</subject><subject>Anthropometry</subject><subject>Area Under Curve</subject><subject>Blood Glucose - metabolism</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Flutamide - therapeutic use</subject><subject>Glucose Tolerance Test</subject><subject>Hormones - blood</subject><subject>Humans</subject><subject>Leptin - blood</subject><subject>Original Paper</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - drug therapy</subject><issn>1663-2818</issn><issn>0301-0163</issn><issn>1663-2826</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpt0M1LwzAYBvAgihtzB8-CBAXBw7RJuiQ9ytjcYDDRyY4la95unf0yaSf9783cmCDmkkB-PHnzIHRJvAdC-sGj55bwPSZOUJtwznpUUn56PBPZQl1rNzvGpAiIOEct4nPiUyrbaDGFskpyPIUtpBZP8siAsoB1bZJ8hUdpXaks0YDnazCqbLCziyKDHH8l1Rq_FGkTNbZKIjzbKtPgtybXxt1foLNYpRa6h72D3kfD-WDcm86eJ4OnaS9ifV71AhEzHgceEW427jNGOe8Dp5rIAPSSE81jkAQYARL5UisQsu_JSCghg6Vcsg662-eWpviswVZhltgI0lTlUNQ2FIRxTkXg4O0fuClqk7vZQuLxgFLhCeHU_V5FprDWQByWJsncxxwKd3WHx7qdvT4k1ssM9K88lOvAzR58KLMCcwTj1-FPQljq2KGrf9H-jW96dYzU</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Sahin, Ibrahim</creator><creator>Serter, Rustu</creator><creator>Karakurt, Feridun</creator><creator>Demirbas, Berrin</creator><creator>Guler, Serdar</creator><creator>Culha, Cavit</creator><creator>Taskapan, Cagatay</creator><creator>Aral, Yalcin</creator><general>S. 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Methods: 20 women with PCOS and 20 controls were enrolled in the study. Leptin levels and leptin response to an oral glucose tolerance test were assessed in both groups before and after a 4-week flutamide therapy period. Results: The leptin levels were similar in both groups at baseline. In the PCOS group, leptin levels and area under curve for leptin levels increased significantly after flutamide treatment. Conclusions: Women with PCOS had similar leptin levels to those of controls with similar age and body mass index. Flutamide treatment led to increased leptin levels and leptin responses to oral glucose tolerance tests in PCOS patients. Further studies are needed to gain insights into the clinical consequences of these effects of flutamide.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>14614228</pmid><doi>10.1159/000074037</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Androgen Antagonists - therapeutic use Anthropometry Area Under Curve Blood Glucose - metabolism Case-Control Studies Female Flutamide - therapeutic use Glucose Tolerance Test Hormones - blood Humans Leptin - blood Original Paper Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - drug therapy |
| title | Leptin Levels Increase during Flutamide Therapy in Women with Polycystic Ovary Syndrome |
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