The Low Gonadotropin-Independent Constitutive Production of Testicular Testosterone Is Sufficient to Maintain Spermatogenesis

Spermatogenesis is thought to critically depend on the high intratesticular testosterone (T) levels induced by gonadotropic hormones. Strategies for hormonal male contraception are based on disruption of this regulatory mechanism through blockage of gonadotropin secretion. Although exogenous T or T...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-11, Vol.100 (23), p.13692-13697
Hauptverfasser:	Zhang, Fu-Ping, Pakarainen, Tomi, Poutanen, Matti, Toppari, Jorma, Huhtaniemi, Ilpo
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases - metabolism Anatomy & physiology Androgens Androgens - metabolism Animals Biological Sciences Birth control Colforsin - metabolism Flutamide - pharmacology Gonadotropins Gonadotropins - metabolism Histology Homozygote Hormones Humans Immunohistochemistry Leydig cells Male Meiosis Mice Mice, Inbred C57BL Mice, Knockout Phenotype Protamines Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Sex hormones Signal Transduction Spermatids Spermatogenesis Testes Testis - pathology Testosterone - biosynthesis Testosterone - metabolism Thrombospondins - metabolism Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!